Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (NCT07699159)
Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM): A Master Observational Trial
π©Ί Plain-English Summary (8th-Grade Level)
The Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM) Master Observational Trial is a prospective, longitudinal observational study that seeks to improve clinical care for youth with multiple mental health conditions (MMHC), also known as mental health multimorbidity in the literature. MMHC is conceptualized as the presence of two or more mental health diagnoses under the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). MMHC is common in youth seeking mental health services and is associated with less favorable outcomes and greater health services utilization. Mental health disorders also accumulate in youth over time. The Master Observational Trial (MOT) will investigate MMHC in critical developmental periods in youth and identify risk and protective factors that will provide a mechanistic understanding of how MMHC develops over time. A subset of participants will also enroll in a Deep Phenotyping Cohort, which includes enhanced clinical and cognitive assessments and multimodal neuroimaging to investigate neurobiological mechanisms underlying MMHC and identify potential biomarkers of illness complexity and progression. In the near future, we aim to add to the current protocol to embed both a clinical trials network for youth mental health in Ontario and Calgary within the CALM study and add digital phenotyping using wearable technology to generate digital and physiological markers of MMHC. The current protocol focuses on establishing the longitudinal MOT cohort and Deep Phenotype Cohort only as a ο¬rst step towards these long term CALM goals.
Who can join: Review the eligibility criteria below.
Location: University of Calgary β Calgary, Alberta
Age range: 11 Years to 24 Years
π "Do I Qualify?" β 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria β
π All Participating Trial Locations (6 Sites)
- University of Calgary β Calgary, Alberta
- McMaster Children's Hospital, Hamilton Health Sciences β Hamilton, Ontario
- Children's Hospital of Eastern Ontario Research Institute β Ottawa, Ontario
- The Royal Ottawa Mental Health Centre β Ottawa, Ontario
- The Hospital for Sick Children β Toronto, Ontario
- Centre for Addiction and Mental Health (CAMH) β Toronto, Ontario
π Contact the Study Coordinator
Phone: (416) 535-8501
Email: louise.gallagher@camh.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
π° Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Multiple Mental Health Conditions clinical trials
π‘ How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.