First-in-Human Trial of VBC108 in Participants With Advanced Malignant Solid Tumors (NCT07700160)
Phase 1/2a Open-label Clinical Trial Evaluating VBC108, a CLDN18.2 and CDH17-directed Bi-specific Antibody Drug Conjugate, in Participants With Advanced Malignant Solid Tumors
🩺 Plain-English Summary (8th-Grade Level)
This is a multicenter, open-label, multiple-dose, FIH Phase 1/2a trial. The Phase 1 portion uses Bayesian optimal interval (BOIN) design to escalate and determine the MTD and/or RP2D with potential backfill cohorts. The Phase 2a portion consists of dose optimization followed by cohort expansion to confirm safety and tolerability and to further evaluate the efficacy of the selected RP2D in selected solid tumor malignancies for VBC108.
Who can join: Review the eligibility criteria below.
Location: City of Hope Medical Center — Duarte, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (12 Sites)
- City of Hope Medical Center — Duarte, California
- START Midwest, LLC — Grand Rapids, Michigan
- Laura and Issac Perlmutter Cancer Center — New York, New York
- Next Oncology - Oncology — San Antonio, Texas
- NEXT Oncology Virginia — Fairfax, Virginia
- GenesisCare North Shore — St Leonards, New South Wales
- One Clinical Research — Perth, Western Australia
- Beijing Cancer Hospital — Beijing, Beijing Municipality
- Beijing GoBroad Hospital — Beijing, Beijing Municipality
- Zhongshan Hospital — Shanghai, Shanghai Municipality
- The First Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang
- Zhejiang Cancer Hospital — Hangzhou, Zhejiang
📞 Contact the Study Coordinator
Phone: (580) 035-9085
Email: jun.yan@VelaVigo.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Solid Tumors
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- QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations — Denver, Colorado
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- A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer — Scottsdale, Arizona
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Explore by condition: All Advanced Solid Tumors clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.