Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life (NCT07719088)
An Examination of Psilocybin Effects on Biomarkers of Longevity, Healthy Aging, and Purpose in Life
🩺 Plain-English Summary (8th-Grade Level)
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults. Up to 50 participants will be enrolled aged 60-80 who will be randomized with equal allocation to one of four intervention groups: (1) receipt of one 25 mg dose of psilocybin; (2) receipt of two 25 mg doses of psilocybin separated by four weeks; (3) receipt of three 25 mg doses, with each dose separated by four weeks; or (4) wait-list comparator condition that does not receive psilocybin. Biomarkers of aging, cognitive performance, and behavioral measures will be assessed at baseline and longitudinally over a 12-month follow-up period. The primary endpoint occurs at the Week 16 visit. Participants randomized to the wait-list condition will be offered a single 25 mg dose of psilocybin following conclusion of the 12-month follow-up period. Findings from this Phase I study will inform dose selection for a Phase II study should results indicate a potential impact of psilocybin on relevant study endpoints.
Who can join: Review the eligibility criteria below.
Location: Vail Health Behavioral Health — Edwards, Colorado
Age range: 60 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Vail Health Behavioral Health — Edwards, Colorado
📞 Contact the Study Coordinator
Phone: (970) 855-7374
Email: bhic@vailhealth.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aging
- A Pilot Study on Reverse Aging (The REVERSE Study) — Cincinnati, Ohio
- Feasibility of Home-based tES for Older Adults at Risk of Falling — Roslindale, Massachusetts
- Heat, Microvascular Function and Aging — Milwaukee, Wisconsin
- Protein Quantity and Quality in Older Subjects — Hamilton, Ontario
- Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse — Salt Lake City, Utah
- Effect of a Daily Supplement on Plasma PAI-1 Levels — Los Angeles, California
Explore by condition: All Aging clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.