Semaglutide for Low Back Pain (NCT07731256)
A Randomized-Controlled Trial of Semaglutide for Patients With Chronic Low Back Pain and Obesity
🩺 Plain-English Summary (8th-Grade Level)
Low back pain is the leading cause of disability in the United States, and obesity is a major risk factor for its development. GLP-1 receptor agonists such as Semaglutide have emerged as effective weight loss agents that may also reduce chronic pain through weight reduction and other mechanisms. This randomized, double-blind, placebo-controlled trial will enroll 250 adults with chronic low back pain and obesity, randomized 1:1 to weekly Semaglutide 2.4 mg or placebo for 52 weeks. The primary outcome is change in low back pain severity, with secondary outcomes including pain-related disability and quality of life.
Who can join: Review the eligibility criteria below.
Location: The University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- The University of Alabama at Birmingham — Birmingham, Alabama
- Washington University School of Medicine — St Louis, Missouri
📞 Contact the Study Coordinator
Phone: (314) 722-0896
Email: lizwilson@wustl.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Lower Back Pain
- Improving Access to Chiropractic Care in Community Health Centers — Boston, Massachusetts
- Peripheral Nerve Stimulation With the SPRINT® System in Chronic PSIJC Pain — Charleston, South Carolina
- Electronic Approach to the Human Massage Therapist — Rochester, Minnesota
- Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain — Napa, California
- Investigating Medical Massage Therapy for Patients With Sub-Acute Lower Back Pain — Joint Base Lewis McChord, Washington
Explore by condition: All Lower Back Pain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.