A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age (NCT07742644)
A Phase 3a, Observer-blind, Randomized, Controlled Study to Demonstrate Lot-to-lot Consistency and Evaluate the Immunogenicity and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine Compared With ProQuad, Administered as a Second Dose in Healthy Children 4-6 Years of Age
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate how consistently 3 different manufacturing lots of the GSK's investigational measles, mumps, rubella, and varicella (MMRVNS) vaccine will produce an immune response. It will also compare the overall immune response to the MMRVNS vaccine with that of the Merck licensed measles, mumps, rubella, and varicella (MMRV) vaccine. The vaccines will be given as a second dose to children aged 4 to 6 years who have previously received a first dose of any combination of measles, mumps, rubella, and varicella-containing vaccine(s). The study will also assess the immune response and safety of the MMRVNS and MMRV vaccines when given at the same time as a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus (DTaP-IPV) vaccine. The DTaP-IPV vaccine used is licensed as Kinrix in the United States.
Who can join: Review the eligibility criteria below.
Location: Children's Clinic of Jonesboro, AR — Jonesboro, Arkansas
Age range: 4 Years to 6 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (62 Sites)
Showing the first 25 of 62 sites.
- Children's Clinic of Jonesboro, AR — Jonesboro, Arkansas
- Applied Research Center of Arkansas — Little Rock, Arkansas
- Century Research Institute Inc — Huntington Park, California
- Matrix Clinical Research — Los Angeles, California
- Center for Clinical Trials of Sacramento, Inc. — Sacramento, California
- Center for Clinical Trials of San Gabriel — West Covina, California
- BioMD Clinical Research — Coral Gables, Florida
- D&H Pompano Research Center LLC — Margate, Florida
- PAS Research — Tampa, Florida
- Medical Research Partners — Ammon, Idaho
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois
- Kentucky Pediatric/ Adult Research — Bardstown, Kentucky
- Norton Childrens Research Institute — Louisville, Kentucky
- Benchmark Research — Covington, Louisiana
- ACC Pediatric Research — Haughton, Louisiana
- Velocity Clinical Research, Gulfport — Lafayette, Louisiana
- Jefferson City Medical Group PC — Jefferson City, Missouri
- Boeson Research MSO — Missoula, Montana
- Midwest Children's Health Research Institute, LLC — Lincoln, Nebraska
- Midwest Children's Health Research Institute, LLC — Lincoln, Nebraska
- Complete Children's Health — Lincoln, Nebraska
- Complete Children's Health — Lincoln, Nebraska
- Atrium Health — Charlotte, North Carolina
- Senders Pediatrics — Cleveland, Ohio
- Neighbors Clinical Research — Charleston, South Carolina
📞 Contact the Study Coordinator
Phone: (877) 379-3718
Email: GSKClinicalSupportHD@gsk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.