Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial (NCT07746271)
🩺 Plain-English Summary (8th-Grade Level)
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized to antihypertensive medication to a target blood pressure (BP) of \<140/90 mmHg or to no treatment for non-severe hypertension \< 160/110 mmHg (usual care). The primary endpoint is an adverse pregnancy composite comprised of preeclampsia with end-organ damage, medically indicated preterm delivery \<37 weeks 0 days gestation, fetal/neonatal/infant death, or placental abruption.
Who can join: Review the eligibility criteria below.
Location: University of Alabama - Birmingham — Birmingham, Alabama
Age range: 14 Years to 56 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (14 Sites)
- University of Alabama - Birmingham — Birmingham, Alabama
- Regents of the University of California San Francisco — San Francisco, California
- Northwestern University — Chicago, Illinois
- Columbia University — New York, New York
- University of North Carolina - Chapel Hill — Chapel Hill, North Carolina
- Duke University — Durham, North Carolina
- Case Western Reserve University — Cleveland, Ohio
- Ohio State University — Columbus, Ohio
- University of Pennsylvania — Philadelphia, Pennsylvania
- Magee Women's Hospital — Pittsburgh, Pennsylvania
- Brown Univeristy — Providence, Rhode Island
- Baylor College of Medicine — Houston, Texas
- University of Texas - Houston — Houston, Texas
- University of Utah — Salt Lake City, Utah
📞 Contact the Study Coordinator
Phone: (202) 242-2945
Email: rclifton@bsc.gwu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hypertension in Pregnancy
- Mobile Health Interventions to Prevent Heart Disease After Hypertensive Disorders of Pregnancy — Chicago, Illinois
- Mindfulness & Mechanisms Study — Providence, Rhode Island
- Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project — Birmingham, Alabama
- Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients — Chicago, Illinois
- Postpartum Evaluation of Nifedipine and Enalapril for Hypertension — Omaha, Nebraska
Explore by condition: All Hypertension in Pregnancy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.