Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance (NCT07759336)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis. Researchers will compare duloxetine to a placebo (a look-alike substance that contains no drug) to see if duloxetine works to improve walking ability in patients with knee osteoarthritis. At study visits, participants will complete surveys, perform physical function tasks, undergo non-invasive brain imaging, and undergo sensory testing.
Who can join: Review the eligibility criteria below.
Location: University of Pittsburgh - Center for Innovation in Pain Care (Research) — Pittsburgh, Pennsylvania
Age range: 45 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Pittsburgh - Center for Innovation in Pain Care (Research) — Pittsburgh, Pennsylvania
📞 Contact the Study Coordinator
Phone: (412) 677-0575
Email: bea51@pitt.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Knee Osteoarthritis (Knee OA)
- Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR) — Toronto, Ontario
- Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis — Philadelphia, Pennsylvania
- Advanced Brain Imaging-TKA (fMRI-TKA) — Ottawa, Ontario
- Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain — Charlottesville, Virginia
Explore by condition: All Knee Osteoarthritis (Knee OA) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.