Non-invasive Prediction of EArly Cardiac rEjection (NCT07770659)
Predictive Modeling of Acute Rejection in Pediatric Heart Transplant Recipients
🩺 Plain-English Summary (8th-Grade Level)
Acute rejection remains a major cause of morbidity and mortality in pediatric patients after heart transplant. In order to screen for rejection, most centers perform heart catheterizations with endomyocardial biopsies frequently in the first year post transplant and then every 1-2 years thereafter; these biopsies are associated with complications, can cause significant anxiety in patients and family members, and are a significant cost for the healthcare system. This project will evaluate non-invasive methods of detecting rejection using cardiac magnetic resonance imaging and blood testing with a goal to reduce the required number of cardiac catheterizations.
Who can join: Review the eligibility criteria below.
Location: Arkansas Children's Hospital — Little Rock, Arkansas
Age range: 6 Years to 25 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (22 Sites)
- Arkansas Children's Hospital — Little Rock, Arkansas
- Children's Hospital of Los Angeles — Los Angeles, California
- UCLA — Los Angeles, California
- Lucile Packard Children's Hospital at Stanford — Palo Alto, California
- Rady Children's Hospital — San Diego, California
- Children's Hospital Colorado — Denver, Colorado
- University of Florida — Gainesville, Florida
- Joe DiMaggio Children's Hospital — Hollywood, Florida
- Children's Hospital of Atlanta — Atlanta, Georgia
- Lurie Children's Hospital — Chicago, Illinois
- Riley Children's Hospital — Indianapolis, Indiana
- Boston Children's Hospital — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- Washington University — St Louis, Missouri
- Mount Sinai Kravis Children's Hospital — New York, New York
- Columbia University — New York, New York
- Nationwide Children's Hospital — Columbus, Ohio
- Vanderbilt University Medical Center — Nashville, Tennessee
- Texas Children's Hospital — Houston, Texas
- UT Health Houston — Houston, Texas
- Seattle Children's Hospital — Seattle, Washington
- Medical College of Wisconsin — Milwaukee, Wisconsin
📞 Contact the Study Coordinator
Phone: (615) 322-7447
Email: PEACE@vumc.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Heart Transplant
- OCS DCD Heart + CAP Continued Follow-Up — La Jolla, California
- XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP) — La Jolla, California
- US National OCS Heart Perfusion (OHP) Registry — Phoenix, Arizona
- Randomized Trial of SGLT2i in Heart Transplant Recipients — Palo Alto, California
- Belatacept in Heart Transplantation — Los Angeles, California
Explore by condition: All Heart Transplant clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.