PREPUP: A Randomized Trial of Bonvadis® Versus Collagenase Ointment in Diabetic Foot Ulcers (NCT07779239)
A Prospective, Multicenter, Multi-Product, Comparative Effectiveness, Randomized Controlled Clinical Trial Evaluating a Novel Wound Bed Optimization Technology (NWBOT) and Standard of Care (SOC) Versus Clostridial Collagenase Ointment (CCO) Plus SOC in Diabetic Foot Ulcers, With Matched-Control Comparison to Topical Hydrogel and Comparisons to Synthetic Standard-of-Care and Topical Collagen Comparator Cohorts.
🩺 Plain-English Summary (8th-Grade Level)
This study is designed to evaluate topical wound products for DFUs using a hybrid design that combines prospectively randomized treatment arms with external control cohorts.
Who can join: Review the eligibility criteria below.
Location: Site #4 — North Port, Florida
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Site #4 — North Port, Florida
- Site #3 — Palm Coast, Florida
- Site #6 — South Miami, Florida
- Site #2 — Metairie, Louisiana
- Site #8 — Brooklyn, New York
- Site #7 — Akron, Ohio
- Site #10 — Circleville, Ohio
- Site #9 — Tulsa, Oklahoma
- Site #1 — Monroeville, Pennsylvania
- Site #5 — Philadelphia, Pennsylvania
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Diabetic Foot Ulcers (DFUs)
- Clinical Trial Evaluating an Amnion Membrane Allograft for Use in the Management of Non- Healing Diabetic Foot Ulcers Versus Standard Of Care — Roanoke, Virginia
- Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care — Coconut Creek, Florida
- Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers — Phoenix, Arizona
- Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing — Coconut Creek, Florida
Explore by condition: All Diabetic Foot Ulcers (DFUs) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.