Physical Activity Modifies Exercise Responsiveness (NCT07792967)
Physical Activity Modifies Exercise Responsiveness: Implications for Rehabilitation in Veterans
🩺 Plain-English Summary (8th-Grade Level)
Exercise is the cornerstone of rehabilitation and an essential part of treatment plans for many chronic conditions; however, our understanding of why certain individuals respond positively to exercise while others do not remains incomplete. Physical inactivity and sedentary behavior have reached epidemic levels, coinciding with alarmingly high levels of multimorbidity in Veterans that, the investigators believe, impair exercise responsiveness and rehabilitation efficacy by disrupting the regulation of redox homeostasis and redox signaling by the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). This project will use complementary approaches including 1) the Sit Less, Interact, Move More (SLIMM) intervention, and 2) PB125 to target Nrf2 and break the cycle of sedentary behavior, redox stress, functional impairments, and worsening multimorbidity in older Veterans.
Who can join: Review the eligibility criteria below.
Location: VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah
Age range: 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah
📞 Contact the Study Coordinator
Phone: (801) 582-1565
Email: Joel.Trinity@va.gov
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Multimorbidity
- High-Risk Veteran Initiative — Sepulveda, California
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- Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of Complex Health Conditions — Aurora, Colorado
Explore by condition: All Multimorbidity clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.