Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH) (NCT00626990)
Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial.
🩺 Plain-English Summary (8th-Grade Level)
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether giving temozolomide during and/or after radiation therapy is more effective than radiation therapy alone in treating anaplastic glioma. PURPOSE: This randomized phase III trial is studying giving temozolomide during and/or after radiation therapy to see how well it works compared to radiation therapy alone in treating patients with anaplastic glioma.
Who can join: Review the eligibility criteria below.
Location: Arizona Oncology Services Foundation — Phoenix, Arizona
Age range: 18 Years to 120 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (132 Sites)
Showing the first 25 of 132 sites.
- Arizona Oncology Services Foundation — Phoenix, Arizona
- Cedars-Sinai Medical Center — Los Angeles, California
- UCSF University of California San Francisco Medical Center-Mount Zion — San Francisco, California
- University of Florida — Gainesville, Florida
- Mayo Clinic in Florida — Jacksonville, Florida
- Florida Hospital — Orlando, Florida
- Emory University — Atlanta, Georgia
- Memorial Health University Medical Center — Savannah, Georgia
- Northwestern University — Chicago, Illinois
- Loyola University Medical Center — Maywood, Illinois
- Oncology Associates PC — Fort Wayne, Indiana
- Parkview Hospital — Fort Wayne, Indiana
- Saint Vincent Oncology Center — Indianapolis, Indiana
- McFarland Clinic — Ames, Iowa
- June E. Nylen Cancer Center — Sioux City, Iowa
- Via Christi Regional Medical Center — Wichita, Kansas
- Wesley Medical Center — Wichita, Kansas
- Maine Medical Center — Scarborough, Maine
- Boston Medical Center — Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts
- Massachussets General Hospital Cancer Center — Boston, Massachusetts
- Saint Joseph Mercy Hospital — Ann Arbor, Michigan
- Henry Ford Hospital — Detroit, Michigan
- West Michigan Cancer Center — Kalamazoo, Michigan
- St John's Mercy Medical Center — St Louis, Missouri
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Brain and Central Nervous System Tumors
- 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer — Detroit, Michigan
- Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma — Birmingham, Alabama
- Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma — Palo Alto, California
- Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma — Birmingham, Alabama
Explore by condition: All Brain and Central Nervous System Tumors clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.