Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma (NCT00887146)
Phase III Intergroup Study of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma
🩺 Plain-English Summary (8th-Grade Level)
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (291 Sites)
Showing the first 25 of 291 sites.
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- Providence Hospital — Mobile, Alabama
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska
- Alaska Oncology and Hematology LLC — Anchorage, Alaska
- Alaska Women's Cancer Care — Anchorage, Alaska
- Anchorage Oncology Centre — Anchorage, Alaska
- Katmai Oncology Group — Anchorage, Alaska
- Providence Alaska Medical Center — Anchorage, Alaska
- Saint Joseph's Hospital and Medical Center — Phoenix, Arizona
- Arizona Oncology-Deer Valley Center — Phoenix, Arizona
- Arizona Oncology Services Foundation — Scottsdale, Arizona
- Kaiser Permanente-Anaheim — Anaheim, California
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California
- Mills-Peninsula Medical Center — Burlingame, California
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California
- Community Cancer Institute — Clovis, California
- University Oncology Associates — Clovis, California
- UC San Diego Moores Cancer Center — La Jolla, California
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
- Cedars Sinai Medical Center — Los Angeles, California
- Memorial Medical Center — Modesto, California
- Kaiser Permanente Oakland-Broadway — Oakland, California
- Kaiser Permanente-Ontario — Ontario, California
- UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California
- Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Brain and Central Nervous System Tumors
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- Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH) — Phoenix, Arizona
- Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma — Palo Alto, California
- Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma — Birmingham, Alabama
Explore by condition: All Brain and Central Nervous System Tumors clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.