HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B (NCT01796457)
🩺 Plain-English Summary (8th-Grade Level)
This is an ancillary to the NIDDK-sponsored treatment trials titled: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (NCT01369212) and Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B (NCT01369199). This study will examine the balance between immune regulatory and effector responses in hepatitis B-infected participants enrolled in the HBRN's clinical trials (NCT01369212 and NCT01369199) to define natural history and treatment outcome.
Who can join: Review the eligibility criteria below.
Location: California Pacific Medical Center — San Francisco, California
Age range: 18 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (8 Sites)
- California Pacific Medical Center — San Francisco, California
- University of California San Francisco Medical Center — San Francisco, California
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- University of Minnesota — Plymouth, Minnesota
- Virginia Commonwealth University Medical Center — Richmond, Virginia
- Virginia Mason Medical Center — Seattle, Washington
- Harborview Medical Center — Seattle, Washington
- Toronto Western Hospital Liver Centre — Toronto, Ontario
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hepatitis B
- Entecavir to TAF Switch — Philadelphia, Pennsylvania
- Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure) — Sacramento, California
- HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B — San Francisco, California
- Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus) — Bakersfield, California
- A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease — Orlando, Florida
Explore by condition: All Hepatitis B clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.