🏛️ Verified NIH Record • Updated 2026-07-07
Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus) (NCT06497504)
A Multicenter, Randomized, Double-Blind, Placebo-controlled Study to Assess the Efficacy and Safety of Treatment With Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection on Antiretroviral Treatment
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: GlaxoSmithKline
🩺 Plain-English Summary (8th-Grade Level)
This study will evaluate the efficacy and safety of bepirovirsen compared to placebo in participants with human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infection.
Who can join: Review the eligibility criteria below.
Location: GSK Investigational Site — Bakersfield, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (51 Sites)
Showing the first 25 of 51 sites.
- GSK Investigational Site — Bakersfield, California
- GSK Investigational Site — San Francisco, California
- GSK Investigational Site — Orlando, Florida
- GSK Investigational Site — West Palm Beach, Florida
- GSK Investigational Site — Baltimore, Maryland
- GSK Investigational Site — Minneapolis, Minnesota
- GSK Investigational Site — Hillsborough, New Jersey
- GSK Investigational Site — Almagro,
- GSK Investigational Site — Buenos Aires,
- GSK Investigational Site — Buenos Aires,
- GSK Investigational Site — Buenos Aires,
- GSK Investigational Site — La Plata,
- GSK Investigational Site — Rosario,
- GSK Investigational Site — Aracaju,
- GSK Investigational Site — Campinas,
- GSK Investigational Site — Curitiba,
- GSK Investigational Site — Manaus,
- GSK Investigational Site — Salvador,
- GSK Investigational Site — São Paulo,
- GSK Investigational Site — Ottawa, Ontario
- GSK Investigational Site — Toronto, Ontario
- GSK Investigational Site — Montreal, Quebec
- GSK Investigational Site — Montreal, Quebec
- GSK Investigational Site — Québec, Quebec
- GSK Investigational Site — Marseille,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hepatitis B
- HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B — San Francisco, California
- Entecavir to TAF Switch — Philadelphia, Pennsylvania
- Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure) — Sacramento, California
- HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B — San Francisco, California
- A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease — Orlando, Florida
Explore by condition: All Hepatitis B clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.