Alpha-1 Antitrypsin Deficiency Adult Liver Study (NCT02014415)
Alpha-1 Antitrypsin Deficiency Adult Clinical and Genetic Linkage Study
🩺 Plain-English Summary (8th-Grade Level)
The investigators hypothesize that there is liver injury (inflammation, fibrosis, cirrhosis) in adults with Alpha-1 Antitrypsin Deficiency (AATD), which is asymptomatic, under-recognized, and undiagnosed. In addition, the investigators believe that the genetic and environmental factors that play an important role in the development of alpha-1 antitrypsin (AAT) liver disease, can be identified by comparing a cohort database of clinical disease information to linked biospecimen and DNA samples.
Who can join: Review the eligibility criteria below.
Location: University of California — San Diego, California
Age range: 18 Years
🧪 Interventions in This Study
- Liver Biopsy (Biopsy Group Only) (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- University of California — San Diego, California
- Boston University School of Medicine — Boston, Massachusetts
- Saint Louis University — St Louis, Missouri
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Alpha-1 Antitrypsin Deficiency
- A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD — Fitzroy, Victoria
- The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study — Gainesville, Florida
- Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs — Gainesville, Florida
Explore by condition: All Alpha-1 Antitrypsin Deficiency clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.