A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD (NCT06405633)
A Phase 1b/2a Open-label Single Ascending Doses (SAD) and Multiple Ascending Doses (MAD) Research Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Participants With AATD Pi*ZZ on WVE-006 (RestorAATion-2)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this open-label study is to assess the safety, tolerability, pharmacodynamics, and pharmacokinetics of WVE-006 in participants with alpha-1 antitrypsin deficiency (AATD) following Period 1 single ascending dose (SAD) and Period 2 multiple ascending doses (MAD), respectively.
Who can join: Review the eligibility criteria below.
Location: St. Vincent's Hospital, Melbourne — Fitzroy, Victoria
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- St. Vincent's Hospital, Melbourne — Fitzroy, Victoria
- Dalhousie University - Queen Elizabeth II Health Sciences Centre — Halifax, Nova Scotia
- Inspiration Research Limited — Toronto, Ontario
- Turku University Hospital — Turku,
- Universitaetsklinikum Aachen, AoeR — Aachen,
- Waikato Hospital — Hamilton,
- Queen Elizabeth Hospital, University Hospital Birmingham — Birmingham,
- Cambridge University - Addenbrooke's Hospital — Cambridge,
- Royal Free London NHS Foundation Trust — London,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Alpha-1 Antitrypsin Deficiency
- Alpha-1 Antitrypsin Deficiency Adult Liver Study — San Diego, California
- The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study — Gainesville, Florida
- Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs — Gainesville, Florida
Explore by condition: All Alpha-1 Antitrypsin Deficiency clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.