๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-08-11

A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors (NCT02099058)

A Multicenter, Phase 1/1b, Open-Label, Dose-Escalation Study of ABBV-399, an Antibody Drug Conjugate, in Subjects With Advanced Solid Tumors

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: AbbVie

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combination with osimertinib, erlotinib, and nivolumab in participants with advanced solid tumors likely to express c-Met. Enrollment is closed for the monotherapy arms, Arm A, and Arm D.

Who can join: Review the eligibility criteria below.

Location: Scottsdale Healthcare /ID# 123761 โ€” Scottsdale, Arizona

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (36 Sites)

Showing the first 25 of 36 sites.

  • Scottsdale Healthcare /ID# 123761 โ€” Scottsdale, Arizona
  • City of Hope /ID# 153759 โ€” Duarte, California
  • University of California, Los Angeles /ID# 148295 โ€” Los Angeles, California
  • UC Irvine /ID# 165107 โ€” Orange, California
  • University of California, Davis Comprehensive Cancer Center /ID# 129805 โ€” Sacramento, California
  • Univ of Colorado Cancer Center /ID# 123759 โ€” Aurora, Colorado
  • The University of Chicago Medical Center /ID# 136995 โ€” Chicago, Illinois
  • Ingalls Memorial Hosp /ID# 165876 โ€” Harvey, Illinois
  • Massachusetts General Hospital /ID# 129804 โ€” Boston, Massachusetts
  • Dana-Farber Cancer Institute /ID# 168782 โ€” Boston, Massachusetts
  • Duplicate_Henry Ford Health System /ID# 149857 โ€” Detroit, Michigan
  • Herbert Herman Cancer Center /ID# 149858 โ€” Lansing, Michigan
  • Washington University-School of Medicine /ID# 143798 โ€” St Louis, Missouri
  • Summit Medical Group-Florham Park /ID# 217651 โ€” Florham Park, New Jersey
  • Northwell Health - Monter Cancer Center /ID# 218170 โ€” Lake Success, New York
  • Montefiore Medical Park at Eastchester /ID# 218445 โ€” The Bronx, New York
  • Duke Cancer Center /ID# 123763 โ€” Durham, North Carolina
  • Tennessee Oncology, PLLC /ID# 129802 โ€” Nashville, Tennessee
  • Mary Crowley Cancer Research /ID# 123760 โ€” Dallas, Texas
  • University of Texas MD Anderson Cancer Center /ID# 154648 โ€” Houston, Texas
  • Virginia Cancer Specialists - Fairfax /ID# 165708 โ€” Fairfax, Virginia
  • Universitair Ziekenhuis Antwerpen /ID# 170118 โ€” Edegem, Antwerpen
  • Duplicate_Tampere University Hospital /ID# 165065 โ€” Tampere, Pirkanmaa
  • AP-HM - Hopital de la Timone /ID# 151570 โ€” Marseille, Bouches-du-Rhone
  • Institut Gustave Roussy /ID# 132747 โ€” Villejuif, Val-de-Marne

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—