A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors (NCT02099058)
A Multicenter, Phase 1/1b, Open-Label, Dose-Escalation Study of ABBV-399, an Antibody Drug Conjugate, in Subjects With Advanced Solid Tumors
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combination with osimertinib, erlotinib, and nivolumab in participants with advanced solid tumors likely to express c-Met. Enrollment is closed for the monotherapy arms, Arm A, and Arm D.
Who can join: Review the eligibility criteria below.
Location: Scottsdale Healthcare /ID# 123761 โ Scottsdale, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (36 Sites)
Showing the first 25 of 36 sites.
- Scottsdale Healthcare /ID# 123761 โ Scottsdale, Arizona
- City of Hope /ID# 153759 โ Duarte, California
- University of California, Los Angeles /ID# 148295 โ Los Angeles, California
- UC Irvine /ID# 165107 โ Orange, California
- University of California, Davis Comprehensive Cancer Center /ID# 129805 โ Sacramento, California
- Univ of Colorado Cancer Center /ID# 123759 โ Aurora, Colorado
- The University of Chicago Medical Center /ID# 136995 โ Chicago, Illinois
- Ingalls Memorial Hosp /ID# 165876 โ Harvey, Illinois
- Massachusetts General Hospital /ID# 129804 โ Boston, Massachusetts
- Dana-Farber Cancer Institute /ID# 168782 โ Boston, Massachusetts
- Duplicate_Henry Ford Health System /ID# 149857 โ Detroit, Michigan
- Herbert Herman Cancer Center /ID# 149858 โ Lansing, Michigan
- Washington University-School of Medicine /ID# 143798 โ St Louis, Missouri
- Summit Medical Group-Florham Park /ID# 217651 โ Florham Park, New Jersey
- Northwell Health - Monter Cancer Center /ID# 218170 โ Lake Success, New York
- Montefiore Medical Park at Eastchester /ID# 218445 โ The Bronx, New York
- Duke Cancer Center /ID# 123763 โ Durham, North Carolina
- Tennessee Oncology, PLLC /ID# 129802 โ Nashville, Tennessee
- Mary Crowley Cancer Research /ID# 123760 โ Dallas, Texas
- University of Texas MD Anderson Cancer Center /ID# 154648 โ Houston, Texas
- Virginia Cancer Specialists - Fairfax /ID# 165708 โ Fairfax, Virginia
- Universitair Ziekenhuis Antwerpen /ID# 170118 โ Edegem, Antwerpen
- Duplicate_Tampere University Hospital /ID# 165065 โ Tampere, Pirkanmaa
- AP-HM - Hopital de la Timone /ID# 151570 โ Marseille, Bouches-du-Rhone
- Institut Gustave Roussy /ID# 132747 โ Villejuif, Val-de-Marne
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Solid Tumors Cancer
- Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors โ Boston, Massachusetts
- Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors โ Springdale, Arkansas
- A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors โ Los Angeles, California
- A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors. โ Los Angeles, California
- ORB-021 In Patients With Advanced Solid Tumors โ Scottsdale, Arizona
Explore by condition: All Advanced Solid Tumors Cancer clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.