A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors (NCT02988960)
A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927 and ABBV-181, an Immunotherapy, in Subjects With Advanced Solid Tumors
๐ฉบ Plain-English Summary (8th-Grade Level)
This is a dose-escalation study designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of ABBV-927, and to determine the maximum tolerated dose (MTD) or recommended Phase 2 dose (RPTD) for ABBV-927 when administered as monotherapy or as combination therapy with ABBV-181 in participants with advanced solid tumors.
Who can join: Review the eligibility criteria below.
Location: The Angeles Clinic and Researc /ID# 156324 โ Los Angeles, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (22 Sites)
- The Angeles Clinic and Researc /ID# 156324 โ Los Angeles, California
- The University of Chicago Medical Center /ID# 155264 โ Chicago, Illinois
- Massachusetts General Hospital /ID# 155267 โ Boston, Massachusetts
- Carolina BioOncology Institute /ID# 155265 โ Huntersville, North Carolina
- Tennessee Oncology-Nashville Centennial /ID# 158654 โ Nashville, Tennessee
- University of Texas MD Anderson Cancer Center /ID# 155263 โ Houston, Texas
- Virginia Cancer Specialists - Fairfax /ID# 155266 โ Fairfax, Virginia
- Peninsula Oncology Centre /ID# 164372 โ Frankston, Victoria
- Austin Health /ID# 171189 โ Heidelberg, Victoria
- University Health Network_Princess Margaret Cancer Centre /ID# 200819 โ Toronto, Ontario
- Institut Bergonie /ID# 162665 โ Bordeaux, Gironde
- Duplicate_Institut Regional du Cancer /ID# 163609 โ Montpellier, Herault
- Centre Leon Berard /ID# 162663 โ Lyon, Rhone
- Institut Gustave Roussy /ID# 162666 โ Villejuif, Val-de-Marne
- National Cancer Center Hospital East /ID# 216870 โ Kashiwa-shi, Chiba
- National Cancer Center Hospital /ID# 217758 โ Chuo-ku, Tokyo
- Seoul National University Hospital /ID# 166291 โ Seoul, Seoul Teugbyeolsi
- Yonsei University Health System Severance Hospital /ID# 166292 โ Seoul,
- Hospital Universitario Puerta de Hierro - Majadahonda /ID# 200129 โ Majadahonda, Madrid
- Hospital Universitario Fundacion Jimenez Diaz /ID# 200128 โ Madrid,
- Hospital Universitario HM Sanchinarro /ID# 200127 โ Madrid,
- Hospital Universitario y Politecnico La Fe /ID# 200975 โ Valencia,
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Advanced Solid Tumors Cancer
- A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors โ Scottsdale, Arizona
- Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors โ Boston, Massachusetts
- Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors โ Springdale, Arkansas
- A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors. โ Los Angeles, California
- ORB-021 In Patients With Advanced Solid Tumors โ Scottsdale, Arizona
Explore by condition: All Advanced Solid Tumors Cancer clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.