๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-01-08

A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors (NCT02988960)

A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927 and ABBV-181, an Immunotherapy, in Subjects With Advanced Solid Tumors

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: AbbVie

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is a dose-escalation study designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of ABBV-927, and to determine the maximum tolerated dose (MTD) or recommended Phase 2 dose (RPTD) for ABBV-927 when administered as monotherapy or as combination therapy with ABBV-181 in participants with advanced solid tumors.

Who can join: Review the eligibility criteria below.

Location: The Angeles Clinic and Researc /ID# 156324 โ€” Los Angeles, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (22 Sites)

  • The Angeles Clinic and Researc /ID# 156324 โ€” Los Angeles, California
  • The University of Chicago Medical Center /ID# 155264 โ€” Chicago, Illinois
  • Massachusetts General Hospital /ID# 155267 โ€” Boston, Massachusetts
  • Carolina BioOncology Institute /ID# 155265 โ€” Huntersville, North Carolina
  • Tennessee Oncology-Nashville Centennial /ID# 158654 โ€” Nashville, Tennessee
  • University of Texas MD Anderson Cancer Center /ID# 155263 โ€” Houston, Texas
  • Virginia Cancer Specialists - Fairfax /ID# 155266 โ€” Fairfax, Virginia
  • Peninsula Oncology Centre /ID# 164372 โ€” Frankston, Victoria
  • Austin Health /ID# 171189 โ€” Heidelberg, Victoria
  • University Health Network_Princess Margaret Cancer Centre /ID# 200819 โ€” Toronto, Ontario
  • Institut Bergonie /ID# 162665 โ€” Bordeaux, Gironde
  • Duplicate_Institut Regional du Cancer /ID# 163609 โ€” Montpellier, Herault
  • Centre Leon Berard /ID# 162663 โ€” Lyon, Rhone
  • Institut Gustave Roussy /ID# 162666 โ€” Villejuif, Val-de-Marne
  • National Cancer Center Hospital East /ID# 216870 โ€” Kashiwa-shi, Chiba
  • National Cancer Center Hospital /ID# 217758 โ€” Chuo-ku, Tokyo
  • Seoul National University Hospital /ID# 166291 โ€” Seoul, Seoul Teugbyeolsi
  • Yonsei University Health System Severance Hospital /ID# 166292 โ€” Seoul,
  • Hospital Universitario Puerta de Hierro - Majadahonda /ID# 200129 โ€” Majadahonda, Madrid
  • Hospital Universitario Fundacion Jimenez Diaz /ID# 200128 โ€” Madrid,
  • Hospital Universitario HM Sanchinarro /ID# 200127 โ€” Madrid,
  • Hospital Universitario y Politecnico La Fe /ID# 200975 โ€” Valencia,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—