Reversal of Lipid-Induced Insulin Resistance (NCT02193295)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).
Who can join: Review the eligibility criteria below.
Location: Magnetic Resonance Research Center (MRRC) — New Haven, Connecticut
Age range: 18 Years to 90 Years
🧪 Interventions in This Study
- Caloric Restriction (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Magnetic Resonance Research Center (MRRC) — New Haven, Connecticut
- Yale Center for Clinical Investigation HRU — New Haven, Connecticut
📞 Contact the Study Coordinator
Phone: (203) 785-5447
Email: kitt.petersen@yale.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Insulin Resistance clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.