Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas (NCT02503423)
Phase 1-2 Study of the Safety, Pharmacokinetics, and Preliminary Activity of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
๐ฉบ Plain-English Summary (8th-Grade Level)
This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with advanced solid tumors or lymphoma for whom standard life-prolonging measures are not available.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham โ Birmingham, Alabama
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (68 Sites)
Showing the first 25 of 68 sites.
- University of Alabama at Birmingham โ Birmingham, Alabama
- HonorHealth Research Institute โ Scottsdale, Arizona
- USC/Norris Comprehensive Cancer Center โ Los Angeles, California
- Cedars-Sinai Medical Center โ Los Angeles, California
- UC Davis Medical Center โ Sacramento, California
- Simlow Cancer Hospital at Yale โ New Haven, Connecticut
- Emory University winship Cancer Institute โ Atlanta, Georgia
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University โ Chicago, Illinois
- The Sidney Kimmel Comprehensive Cancer Center at John Hopkins โ Baltimore, Maryland
- Tufts Medical Center โ Boston, Massachusetts
- Dana-Farber Cancer Institute โ Boston, Massachusetts
- University of Michigan โ Ann Arbor, Michigan
- Dartmouth-Hitchcock Medical Center (DHMC) โ Lebanon, New Hampshire
- Summit Medical Group - Florham Park Campus/Atlantic Health โ Florham Park, New Jersey
- Roswell Park Cancer Institute โ Buffalo, New York
- New York University Langone Medical Center โ New York, New York
- New York Presbyterian Hospital Columbia University Medical Center โ New York, New York
- Icahn School of Medicine at Mount Sinai โ New York, New York
- Rochester Skin Lymphoma Medical Group โ Rochester, New York
- Wake Forest Baptist Health โ Winston-Salem, North Carolina
- The Ohio State University and Wexner Medical Center, James Cancer Hospital โ Columbus, Ohio
- University of Oklahoma Stephenson Cancer Center โ Oklahoma City, Oklahoma
- Oregon Health and Science University โ Portland, Oregon
- West Penn Hospital โ Pittsburgh, Pennsylvania
- Hollings Cancer Center โ Charleston, South Carolina
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Study of the Effect of Rifampicin on the Pharmacokinetics (PK) of Multiple Doses of Cediranib in Patients With Solid Tumours โ Edmonton, Alberta
- Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) โ Santa Monica, California
- A Safety and Efficacy Extension Study of Pertuzumab in Patients With Solid Tumors Previously Enrolled in a Hoffmann-La Roche-Sponsored Pertuzumab Clinical Trial โ Porto Alegre, Rio Grande do Sul
- Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors โ Los Angeles, California
- Flavored, Oral Irinotecan VAL-413 (Orotecanยฎ) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors โ Phoenix, Arizona
Explore by condition: All Solid Tumors clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.