๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-03-17

Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas (NCT02503423)

Phase 1-2 Study of the Safety, Pharmacokinetics, and Preliminary Activity of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas

๐Ÿ”ต Active, Not Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Taiho Oncology, Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with advanced solid tumors or lymphoma for whom standard life-prolonging measures are not available.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham โ€” Birmingham, Alabama

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (68 Sites)

Showing the first 25 of 68 sites.

  • University of Alabama at Birmingham โ€” Birmingham, Alabama
  • HonorHealth Research Institute โ€” Scottsdale, Arizona
  • USC/Norris Comprehensive Cancer Center โ€” Los Angeles, California
  • Cedars-Sinai Medical Center โ€” Los Angeles, California
  • UC Davis Medical Center โ€” Sacramento, California
  • Simlow Cancer Hospital at Yale โ€” New Haven, Connecticut
  • Emory University winship Cancer Institute โ€” Atlanta, Georgia
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University โ€” Chicago, Illinois
  • The Sidney Kimmel Comprehensive Cancer Center at John Hopkins โ€” Baltimore, Maryland
  • Tufts Medical Center โ€” Boston, Massachusetts
  • Dana-Farber Cancer Institute โ€” Boston, Massachusetts
  • University of Michigan โ€” Ann Arbor, Michigan
  • Dartmouth-Hitchcock Medical Center (DHMC) โ€” Lebanon, New Hampshire
  • Summit Medical Group - Florham Park Campus/Atlantic Health โ€” Florham Park, New Jersey
  • Roswell Park Cancer Institute โ€” Buffalo, New York
  • New York University Langone Medical Center โ€” New York, New York
  • New York Presbyterian Hospital Columbia University Medical Center โ€” New York, New York
  • Icahn School of Medicine at Mount Sinai โ€” New York, New York
  • Rochester Skin Lymphoma Medical Group โ€” Rochester, New York
  • Wake Forest Baptist Health โ€” Winston-Salem, North Carolina
  • The Ohio State University and Wexner Medical Center, James Cancer Hospital โ€” Columbus, Ohio
  • University of Oklahoma Stephenson Cancer Center โ€” Oklahoma City, Oklahoma
  • Oregon Health and Science University โ€” Portland, Oregon
  • West Penn Hospital โ€” Pittsburgh, Pennsylvania
  • Hollings Cancer Center โ€” Charleston, South Carolina

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Solid Tumors clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—