πŸ›οΈ Verified NIH Record β€’ Updated 2026-08-04

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma (NCT02519348)

A Study of Safety, Tolerability, and Clinical Activity of Durvalumab and Tremelimumab Administered as Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Subjects With Advanced Hepatocellular Carcinoma

πŸ”΅ Active, Not Recruiting Phase2 πŸ’Š Investigational Drug / Biologic Sponsor: MedImmune LLC

🩺 Plain-English Summary (8th-Grade Level)

This is a multicenter, open-label, stratified, randomized study to evaluate the safety, tolerability, antitumor activity, pharmacokinetics, pharmacodynamics, and immunogenicity of durvalumab or tremelimumab monotherapy, or durvalumab in combination with tremelimumab or bevacizumab in advanced hepatocellular carcinoma.

Who can join: Review the eligibility criteria below.

Location: Research Site β€” Phoenix, Arizona

Age range: 18 Years to 99 Years

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (44 Sites)

Showing the first 25 of 44 sites.

  • Research Site β€” Phoenix, Arizona
  • Research Site β€” San Francisco, California
  • Research Site β€” New Haven, Connecticut
  • Research Site β€” Jacksonville, Florida
  • Research Site β€” Tampa, Florida
  • Research Site β€” Indianapolis, Indiana
  • Research Site β€” Boston, Massachusetts
  • Research Site β€” New York, New York
  • Research Site β€” Stony Brook, New York
  • Research Site β€” Durham, North Carolina
  • Research Site β€” Portland, Oregon
  • Research Site β€” Philadelphia, Pennsylvania
  • Research Site β€” Philadelphia, Pennsylvania
  • Research Site β€” Nashville, Tennessee
  • Research Site β€” Dallas, Texas
  • Research Site β€” Seattle, Washington
  • Research Site β€” Hangzhou,
  • Research Site β€” Nanjing,
  • Research Site β€” Shanghai,
  • Research Site β€” Hong Kong,
  • Research Site β€” Shatin,
  • Research Site β€” Benevento,
  • Research Site β€” Milan,
  • Research Site β€” Roma,
  • Research Site β€” Chūōku,

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—