Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer (NCT03210103)
A Randomized Trial of Treatment De-Escalation for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: Radiotherapy vs. Trans-Oral Surgery (ORATOR II)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this randomized treatment de-escalation study is to formally compare outcomes in HPV related oropharyngeal cancer tumors treated with a primary radiotherapy versus a primary surgical approach, to provide a high level of evidence to guide the selection of treatment options for a subsequent phase III trial
Who can join: Review the eligibility criteria below.
Location: Gold Coast University Hospital — Gold Coast, Queensland
Age range: 18 Years
🧪 Interventions in This Study
- Radiation (RADIATION)
- Transoral Surgery (TOS) + Neck Dissection (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- Gold Coast University Hospital — Gold Coast, Queensland
- Royal Adelaide Hospital — Adelaide,
- Tom Baker Cancer Centre — Calgary, Alberta
- BC Cancer — Vancouver, British Columbia
- London Regional Cancer Program — London, Ontario
- Ottawa Hospital Research Institute — Ottawa, Ontario
- Sunnybrook Research Institute — Toronto, Ontario
- University Health Network — Toronto, Ontario
- Jewish General Hospital — Montreal, Quebec
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Oropharyngeal Cancer
- A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC) — Basking Ridge, New Jersey
- De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma — Prince George, British Columbia
- A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers — Bethesda, Maryland
- Men and Women Offering Understanding of Throat HPV — Baltimore, Maryland
- Depression and Adherence in Head and Neck Cancer — Houston, Texas
Explore by condition: All Oropharyngeal Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.