🏛️ Verified NIH Record • Updated 2026-01-28
De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma (NCT03822897)
A Phase II Single Arm Trial of Elective Volume Adjusted De-Escalation Radiotherapy (EVADER) in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Canadian Cancer Trials Group
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to find out whether radiotherapy to some of the lymph node areas can be safely omitted to decrease side effects without increasing the risk of the tumour coming back.
Who can join: Review the eligibility criteria below.
Location: BCCA - Centre for the North — Prince George, British Columbia
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (14 Sites)
- BCCA - Centre for the North — Prince George, British Columbia
- BCCA - Vancouver Cancer Centre — Vancouver, British Columbia
- CancerCare Manitoba — Winnipeg, Manitoba
- Dr. H. Bliss Murphy Cancer Centre — St. John's, Newfoundland and Labrador
- Juravinski Cancer Centre at Hamilton Health Sciences — Hamilton, Ontario
- Kingston Health Sciences Centre — Kingston, Ontario
- Ottawa Hospital Research Institute — Ottawa, Ontario
- Odette Cancer Centre — Toronto, Ontario
- University Health Network — Toronto, Ontario
- The Jewish General Hospital — Montreal, Quebec
- The Research Institute of the McGill University — Montreal, Quebec
- Hotel-Dieu de Quebec — Québec, Quebec
- CIUSSS de l'Estrie - Centre hospitalier — Sherbrooke, Quebec
- Allan Blair Cancer Centre — Regina, Saskatchewan
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Oropharyngeal Cancer
- A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC) — Basking Ridge, New Jersey
- Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer — Gold Coast, Queensland
- A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers — Bethesda, Maryland
- Men and Women Offering Understanding of Throat HPV — Baltimore, Maryland
- Depression and Adherence in Head and Neck Cancer — Houston, Texas
Explore by condition: All Oropharyngeal Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.