POTS NET mRNA Functional Correlation With NET Activity (NCT03218761)
Validation of Norepinephrine Transporter (NET) mRNA as a Measure of Functional NET Expression in Postural Tachycardia Syndrome (POTS)
🩺 Plain-English Summary (8th-Grade Level)
DNA Acetylation can be responsible for significant down-regulation of transcription of the Norepinephrine Transporter (NET). NET is an important clearance transporter that removes norepinephrine (NE) from sympathetic neuronal synapses. Very low levels of NET can "cause" Postural Tachycardia Syndrome (POTS) or make these patients more susceptible to certain medications. Quantified NET messenger RNA (mRNA) levels from a peripheral blood sample may be able to assess NET availability, which is simpler than older methods. This has not been validated against NET function. In this protocol, the investigators seek to assess whether these NET mRNA levels correlate with NET function. The investigators will assess the DHPG (NET dependent NE metabolite):NE ratio in POTS patients and control subjects from both plasma and urine samples.
Who can join: Review the eligibility criteria below.
Location: Vanderbilt University Medical Center — Nashville, Tennessee
Age range: 13 Years to 80 Years
🧪 Interventions in This Study
- NET mRNA level (DIAGNOSTIC_TEST)
- Plasma catechols (DIAGNOSTIC_TEST)
- Urine Catechols (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Vanderbilt University Medical Center — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Postural Tachycardia Syndrome
- Acute Salt Handling in Orthostatic Intolerance — Nashville, Tennessee
- Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention. — La Jolla, California
- Sleep Actigraphy in Postural Tachycardia Syndrome (POTS) — Nashville, Tennessee
- Vagal Stimulation in POTS — Nashville, Tennessee
- fMRI in Postural Tachycardia Syndrome — Hershey, Pennsylvania
- Autonomic Determinants of POTS - Pilot 2 — Nashville, Tennessee
Explore by condition: All Postural Tachycardia Syndrome clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.