ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease (NCT03319485)
A Pivotal Clinical Trial of the Management of the Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Idiopathic Parkinson's Disease With Unilateral Lesioning of the Globus Pallidum Using the ExAblate Neuro System
🩺 Plain-English Summary (8th-Grade Level)
Evaluate the safety and efficacy of unilateral focused ultrasound pallidotomy using the ExAblate 4000 System in the management of dyskinesia symptoms or motor fluctuations for medication refractory, advanced idiopathic Parkinson's disease.
Who can join: Review the eligibility criteria below.
Location: Stanford University Medical Center — Stanford, California
Age range: 30 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Stanford University Medical Center — Stanford, California
- Palm Beach Neuroscience Institute/Sperling Medical Group — Boynton Beach, Florida
- University of Maryland Medical System — Baltimore, Maryland
- Brigham and Women's Hospital — Boston, Massachusetts
- Mayo Clinic — Rochester, Minnesota
- New York University Health Langone — New York, New York
- Weill Cornell Medicine — New York, New York
- The Ohio State Wexner Medical Center — Columbus, Ohio
- Pennsylvania Hospital Department of Neurosurgery — Philadelphia, Pennsylvania
- University of Virginia Health System — Charlottesville, Virginia
- Swedish Medical Center — Seattle, Washington
- Toronto Western Hospital — Toronto, Ontario
- Rambam Health Care — Haifa,
- Fondazione IRCCS Neurological Institute Carlo Besta — Milan,
- Azienda Ospedaliera Universitaria di Verona, Univerista di Verona — Verona,
- Severance Hospital, Yonsei University Health System — Seoul,
- CINAC-Hospital HM Puerta del Sur — Móstoles, Madrid
- Clinica Universidad De Navarra — Pamplona, Navarre
- Chang Bing Show Chwan Memorial Hospital — Changhua,
- St. Mary's Hospital — London,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.