The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial (NCT03447938)
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Randomized Controlled Trial
🩺 Plain-English Summary (8th-Grade Level)
MICS CABG (Minimally invasive coronary surgery), where coronary artery bypass grafting (CABG) is completed through a small incision over the left chest, has evolved to become a safe and less invasive alternative to conventional sternotomy CABG. Several observational studies have suggested significantly shorter time to return to physical activity for MICS CABG patients compared to sternotomy CABG patients. A randomized study is warranted to validate these findings, provide higher level of evidence, and potentially lead to changes in practice. The MIST Trial is a multi-centre, prospective, open label, randomized control trial comparing quality of life and recovery in the early post-operative period, between patients undergoing MICS CABG versus patients undergoing sternotomy CABG. Patients referred for isolated CABG for multi-vessel coronary artery disease and deemed technically suitable for sternotomy CABG as well as for MICS CABG are considered for enrollment into the trial. Quality of life questionnaires (The SF-36, Seattle Angina Questionnaire and EQ-5D-5L) will be used to assess the quality of life and recovery in patients undergoing sternotomy CABG or MICS CABG at 1 month, 3 months, 6 months and 12 months follow up.
Who can join: Review the eligibility criteria below.
Location: University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
Age range: 18 Years
🧪 Interventions in This Study
- MICS CABG (PROCEDURE)
- Conventional CABG (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (13 Sites)
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania
- Gundersen Lutheran Medical Center — La Crosse, Wisconsin
- Universitaire Ziekenhuizen Leuven — Leuven,
- Division of Cardiac Surgery, University of Ottawa Heart Institute — Ottawa, Ontario
- University Health Network — Toronto, Ontario
- Jilin Heart Hospital — Jilin City, Jilin
- Leipzig Heart Institute GmbH — Leipzig, Saxony
- Robert-Bosch-Hospital — Stuttgart,
- Apollo Hospital, Bangalore — Bangalore, Karnataka
- Manipal Hospitals — New Delhi, National Capital Territory of Delhi
- Tokyo Bay Urayasu Ichikawa Medical Center — Urayasu, Chiba
- National University Hospital (NUH) - Singapore — Singapore,
- Far-Eastern Memorial Hospital — Taipei, Taipei
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.