ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis (NCT03517436)
A Prospective, Single-arm, Controlled, Multicenter Study to Establish the Safety and Effectiveness of the CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis Requiring Aortic Valve Replacement
🩺 Plain-English Summary (8th-Grade Level)
This study will monitor the safety and valve performance of the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with symptomatic, severe, calcific aortic stenosis who are at intermediate operative risk for surgical aortic valve replacement (SAVR).
Who can join: Review the eligibility criteria below.
Location: Cedars-Sinai Medical Center — Los Angeles, California
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (23 Sites)
- Cedars-Sinai Medical Center — Los Angeles, California
- Stanford University Medical Center — Stanford, California
- UC Health Northern Colorado (Medical Center of the Rockies) — Loveland, Colorado
- Washington Hospital Center — Washington D.C., District of Columbia
- Sarasota Memorial Hospital — Sarasota, Florida
- Emory University — Atlanta, Georgia
- St. Vincent Medical Group, Inc./St. Vincent Heart Center of Indiana, LLC — Indianapolis, Indiana
- University of Kansas Health System — Kansas City, Kansas
- Cardiovascular Research Institute of Kansas — Wichita, Kansas
- Brigham and Women's Hospital — Boston, Massachusetts
- Henry Ford Hospital — Detroit, Michigan
- Washington University/ Barnes-Jewish Hospital — St Louis, Missouri
- Atlantic Health System Hospital Corp — Morristown, New Jersey
- Columbia University Medical Center/ NYPH — New York, New York
- The Ohio Health Research Institute — Columbus, Ohio
- University of Pennsylvania — Philadelphia, Pennsylvania
- Allegheny - Singer Research Institute — Pittsburgh, Pennsylvania
- Saint Thomas Health — Nashville, Tennessee
- Baylor Heart and Vascular Hospital — Dallas, Texas
- The University of Texas Health Science Center at Houston — Houston, Texas
- University of Texas Memorial Hermann — Houston, Texas
- The Heart Hospital Baylor Plano — Plano, Texas
- Baylor Scott and White, Central Texas — Temple, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aortic Valve Stenosis
- Prolonged Continuous ECG Monitoring Prior to Transcatheter Aortic Valve Implantation — Québec, Quebec
- Inspiris Resilia Durability Registry — Sankt Pölten,
- Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD) — Chandler, Arizona
- Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients — Phoenix, Arizona
- Platelet Adhesion in the Pathobiology of Aortic Stenosis — Charlottesville, Virginia
Explore by condition: All Aortic Valve Stenosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.