Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis (NCT03654053)
Effect of Simvastatin on Hepatic Decompensation and Death in Subjects With High-risk Compensated Cirrhosis
🩺 Plain-English Summary (8th-Grade Level)
This phase III, randomized, double-blind, placebo-controlled, multi-center study seeks to test whether simvastatin, a statin usually used to lower cholesterol to prevent heart problems and strokes, can lower the risk of hepatic decompensation (developing symptoms of cirrhosis) in U.S. Veterans who have compensated cirrhosis (the liver is scarred and damaged but there are no symptoms). The study will also explore how changes or differences in genes effect the safety and effectiveness of using statins and how the use of statins affects quality of life.
Who can join: Review the eligibility criteria below.
Location: San Francisco VA Medical Center, San Francisco, CA — San Francisco, California
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (11 Sites)
- San Francisco VA Medical Center, San Francisco, CA — San Francisco, California
- VA Connecticut Healthcare System West Haven Campus, West Haven, CT — West Haven, Connecticut
- Robley Rex VA Medical Center, Louisville, KY — Louisville, Kentucky
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston, Massachusetts
- Brooklyn Campus of the VA NY Harbor Healthcare System, Brooklyn, NY — Brooklyn, New York
- James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA — Philadelphia, Pennsylvania
- Philadelphia MultiService Center, Philadelphia, PA — Philadelphia, Pennsylvania
- Michael E. DeBakey VA Medical Center, Houston, TX — Houston, Texas
- Hunter Holmes McGuire VA Medical Center, Richmond, VA — Richmond, Virginia
- VA Puget Sound Health Care System Seattle Division, Seattle, WA — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cirrhosis
- Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement — Richmond, Virginia
- Liver Cirrhosis Network Cohort Study — La Jolla, California
- Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis — Los Angeles, California
- Oral Health In Cirrhosis of the Liver (ORACLE) — Richmond, Virginia
- Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis — Ann Arbor, Michigan
Explore by condition: All Cirrhosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.