Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD (NCT03667846)
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With Post Traumatic Stress Disorder
🩺 Plain-English Summary (8th-Grade Level)
This is a double-blind, 2-group randomized controlled trial evaluating the effects of topiramate versus placebo in patients with comorbid PTSD and moderate-to-severe AUD. This trial will provide one of the first rigorous tests of whether the effects of topiramate in AUD generalize to patients with co-occurring PTSD, and one of the first rigorous tests of whether topiramate has beneficial effects on PTSD symptoms in this population. It will be the first study to test whether the rs2832407 genotype predicts clinical response to topiramate for AUD and PTSD in patients with both disorders. Further, it will contribute to the understanding of topiramate's mechanisms of action in the co-morbid AUD/PTSD population, and to the discovery of predictors of treatment response.
Who can join: Review the eligibility criteria below.
Location: New York University School of Medicine — New York, New York
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- New York University School of Medicine — New York, New York
📞 Contact the Study Coordinator
Phone: (646) 754-7454
Email: Dayeon.Cho@nyulangone.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Post Traumatic Stress Disorder
- A Study of Psilocybin for PTSD — Baltimore, Maryland
- RESILIENT : A Self-Managed Online Platform for Victims of Sexual Assault — Québec, Quebec
- Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder — New York, New York
- TMS-fNIRS Personalized Dosing — Tallahassee, Florida
- Targeted Plasticity Therapy for Posttraumatic Stress Disorder — Dallas, Texas
- NightWare and Cardiovascular Health in Women With PTSD — Aurora, Colorado
Explore by condition: All Post Traumatic Stress Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.