๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-13

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma (NCT03778957)

A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination With Either Durvalumab Monotherapy or Durvalumab Plus Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma (EMERALD-1)

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: AstraZeneca

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab and bevacizumab therapy in patients with locoregional hepatocellular carcinoma

Who can join: Review the eligibility criteria below.

Location: Research Site โ€” Costa Mesa, California

Age range: 18 Years to 110 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (166 Sites)

Showing the first 25 of 166 sites.

  • Research Site โ€” Costa Mesa, California
  • Research Site โ€” La Jolla, California
  • Research Site โ€” Orange, California
  • Research Site โ€” Washington D.C., District of Columbia
  • Research Site โ€” Jacksonville, Florida
  • Research Site โ€” Miami, Florida
  • Research Site โ€” Honolulu, Hawaii
  • Research Site โ€” Chicago, Illinois
  • Research Site โ€” Shreveport, Louisiana
  • Research Site โ€” Detroit, Michigan
  • Research Site โ€” Rochester, Minnesota
  • Research Site โ€” St Louis, Missouri
  • Research Site โ€” Stony Brook, New York
  • Research Site โ€” Charlotte, North Carolina
  • Research Site โ€” Cleveland, Ohio
  • Research Site โ€” Portland, Oregon
  • Research Site โ€” Pittsburgh, Pennsylvania
  • Research Site โ€” Sioux Falls, South Dakota
  • Research Site โ€” Memphis, Tennessee
  • Research Site โ€” Dallas, Texas
  • Research Site โ€” Dallas, Texas
  • Research Site โ€” Houston, Texas
  • Research Site โ€” Houston, Texas
  • Research Site โ€” Milwaukee, Wisconsin
  • Research Site โ€” Benowa,

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—