CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer (NCT03933826)
🩺 Plain-English Summary (8th-Grade Level)
Bladder cancer is the most common urinary tract cancer and the 5th most common cancer in the US (1). Yet bladder cancer research is underfunded relative to other common cancers. As a result, bladder cancer care is prone to evidence gaps that produce decision uncertainty for both patients and clinicians. The Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO) for Bladder Cancer Study has the potential to fill these critical evidence gaps, change care pathways for the management of non-muscle-invasive bladder cancer (NMIBC), and provide for personalized, patient-centered care. The purpose of CISTO is to conduct a large prospective study that directly compares the impact of medical management versus bladder removal in recurrent high-grade NMIBC patients with Bacillus Calmette-Guerin (BCG) failure on clinical outcomes and patient and caregiver experience using standardized patient-reported outcomes (PROs).
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (36 Sites)
Showing the first 25 of 36 sites.
- University of Alabama at Birmingham — Birmingham, Alabama
- Mayo Clinic Cancer Center — Phoenix, Arizona
- USC/Norris Comprehensive CA Center — Los Angeles, California
- UCLA — Los Angeles, California
- Hoag Memorial Hospital Presbyterian — Newport Beach, California
- University of Colorado Anschutz Medical Campus — Aurora, Colorado
- University of Miami — Miami, Florida
- H. Lee Moffitt Cancer Center & Research Institute — Tampa, Florida
- Emory University — Atlanta, Georgia
- University of Chicago — Chicago, Illinois
- University of Iowa — Iowa City, Iowa
- University of Kansas Medical Center — Kansas City, Kansas
- LSU Healthcare Network - Multi Specialty Clinic — Metairie, Louisiana
- Johns Hopkins University, School of Medicine — Baltimore, Maryland
- Chesapeake Urology Research Associates — Hanover, Maryland
- Brigham and Women's Hospital — Boston, Massachusetts
- Michigan Medicine Rogel Cancer Center — Ann Arbor, Michigan
- Spectrum Health — Grand Rapids, Michigan
- Comprehensive Urology -- A Division of Michigan Healthcare Professionals — Royal Oak, Michigan
- Albert Einstein College of Medicine — The Bronx, New York
- University of North Carolina — Chapel Hill, North Carolina
- Levine Cancer Institute — Charlotte, North Carolina
- The Ohio State University — Columbus, Ohio
- Stephenson Cancer Center — Oklahoma City, Oklahoma
- Asante Rogue Regional Medical Center — Medford, Oregon
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Bladder Cancer
- Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer — St Louis, Missouri
- Trimodality Therapy With/Out Durvalumab to Treat Patients With Muscle-Invasive Bladder Cancer — Calgary, Alberta
- Determinants of Bladder Cancer Recurrence Study (The DETER Study) — Basking Ridge, New Jersey
- Quality of Life in Patients With Bladder Cancer — New York, New York
- A Phase II Study of Atezolizumab in Combination With Cisplatin + Gemcitabine Before Surgery to Remove the Bladder Cancer — Hartford, Connecticut
- A Diagnostic for the Early Detection of Bladder Cancer — Long Beach, California
Explore by condition: All Bladder Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.