Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics (NCT03953300)
A Phase 4, Multicenter, Randomized, Double-blind, Parallel Group, Placebo Controlled Study to Evaluate the Effect of Benralizumab on Structural and Lung Function Changes in Severe Eosinophilic Asthmatics
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without additional controller medication. Patients who complete treatment will enter 4 weeks follow-up period.
Who can join: Review the eligibility criteria below.
Location: Research Site — Birmingham, Alabama
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (35 Sites)
Showing the first 25 of 35 sites.
- Research Site — Birmingham, Alabama
- Research Site — Los Angeles, California
- Research Site — Jacksonville, Florida
- Research Site — Miami, Florida
- Research Site — Snellville, Georgia
- Research Site — Indianapolis, Indiana
- Research Site — Iowa City, Iowa
- Research Site — Kansas City, Kansas
- Research Site — Ann Arbor, Michigan
- Research Site — Bloomfield Hills, Michigan
- Research Site — Rochester, Minnesota
- Research Site — St Louis, Missouri
- Research Site — Maspeth, New York
- Research Site — New Bern, North Carolina
- Research Site — Winston-Salem, North Carolina
- Research Site — Pittsburgh, Pennsylvania
- Research Site — Galveston, Texas
- Research Site — Lewisville, Texas
- Research Site — Mansfield, Texas
- Research Site — Calgary, Alberta
- Research Site — Aalborg,
- Research Site — Aarhus N,
- Research Site — Copenhagen,
- Research Site — Hvidovre,
- Research Site — Næstved,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Asthma
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- Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma — Bakersfield, California
- Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma — Saraland, Alabama
- Reduce IDentified UNcontrolled Asthma — San Diego, California
- A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma — Little Rock, Arkansas
- REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study — La Jolla, California
Explore by condition: All Asthma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.