Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19) (NCT03963622)
Careful Ventilation in Acute Respiratory Distress Syndrome
🩺 Plain-English Summary (8th-Grade Level)
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations. CAVIARDS consists of an identical 2-arm mechanical ventilation protocol implemented in two different study populations (COVID-19 and non-COVID-19 patients). As per a typical basket trial design, the operational structure of both the COVID-19 substudy (CAVIARDS-19) and non-COVID-19 substudy (CAVIARDS-all) is shared (recruitment, procedures, data collection, analysis, management, etc.).
Who can join: Review the eligibility criteria below.
Location: New York University Grossman School of Medicine — New York, New York
Age range: 18 Years
🧪 Interventions in This Study
- Respiratory Mechanics (OTHER)
- Standard Ventilation Strategy (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (33 Sites)
Showing the first 25 of 33 sites.
- New York University Grossman School of Medicine — New York, New York
- Centro de Educación Médica e Investigaciones Clínicas Dr Norberto Quirno (CEMIC) — Buenos Aires,
- Complejo Médico Policía Federal Argentina Churruca Visca — Buenos Aires,
- Hospital Británico de Buenos Aires — Buenos Aires,
- Sanatorio Anchorena Recoleta — Buenos Aires,
- Sanatorio Mater Dei — Buenos Aires,
- Sanatorio Anchorena San Martín — San Martin,
- St. Michael's Hospital — Toronto,
- Toronto General Hospital — Toronto,
- Toronto Western Hospital — Toronto,
- Pontificia Universidad Católica de Chile — Santiago,
- CHU Amiens-Picardie — Amiens,
- Centre hospitalier universitaire d'Angers — Angers,
- CH Victor Dupouy — Argenteuil,
- CH de Beauvais — Beauvais,
- CHU Bordeaux - Haut Leveque — Bordeaux,
- Hopital de la Cavale Blanche - CHRU Brest — Brest,
- CH de Cholet — Cholet,
- Hopital Intercommunal de Creteil — Créteil,
- CHU Grenoble-Alpes — Grenoble,
- Hopital Roger Salengro - CHU Lille — Lille,
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace — Mulhouse,
- Hopital de l'Archet 1 - CHU de Nice — Nice,
- Hopital Europeen Georges-Pompidou — Paris,
- CHU de Poitiers - La Miletrie — Poitiers,
📞 Contact the Study Coordinator
Phone: (416) 864-6060
Email: laurent.brochard@unityhealth.to
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in ARDS
- Ventilatory Parameters in Predicting Outcomes in ARDS Patients — Saint Cloud, Minnesota
- The APS Phenotyping Study — Fresno, California
Explore by condition: All ARDS clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.