Targeting Orexin to Treat Nicotine Dependence (NCT03999099)
🩺 Plain-English Summary (8th-Grade Level)
Tobacco smoking continues to be the primary cause of preventable mortality in the United States. Despite the availability of smoking cessation aids, the majority of those trying to quit smoking end up relapsing. Thus, there is a strong need to evaluate alternative treatment targets such as orexin antagonists, which have shown promise in preclinical models at reducing the motivational aspects of drug use.The current work will evaluate the influence of orexin antagonism on several factors impacting the motivation to smoke.
Who can join: Review the eligibility criteria below.
Location: McLean Hospital — Belmont, Massachusetts
Age range: 18 Years to 50 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- McLean Hospital — Belmont, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Nicotine Dependence
- Electronic Cigarettes and Reactivity to Smoking Cues — Belmont, Massachusetts
- Sex Differences in E-Cigarette Perception — New Haven, Connecticut
- NeuroControl of Nicotine Dependence — Columbia, Missouri
- Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use — Los Angeles, California
- Orexin s Role in the Neurobiology of Substance Use Disorder — Baltimore, Maryland
Explore by condition: All Nicotine Dependence clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.