Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use (NCT07698470)
Cue-Exposure Response Evaluation: Brain Reactivity to ONPs
🩺 Plain-English Summary (8th-Grade Level)
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effects of a single 6 mg oral nicotine pouch on subjective craving and prefrontal neural responses to smoking-related cues using functional near-infrared spectroscopy (fNIRS). Participants will complete assessments before and after nicotine pouch administration following overnight nicotine abstinence to characterize changes in craving and neural cue reactivity.
Who can join: Review the eligibility criteria below.
Location: University of Southern California - 3641 Watt Way (HNB B22) — Los Angeles, California
Age range: 21 Years to 55 Years
🧪 Interventions in This Study
- Oral Nicotine Pouch (OTHER)
- Smoking Cue Reactivity Task (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- University of Southern California - 3641 Watt Way (HNB B22) — Los Angeles, California
📞 Contact the Study Coordinator
Phone: (213) 821-0807
Email: USCONPStudy@gmail.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.