Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma (NCT04044768)
A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEARβ’ T Cells in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
π©Ί Plain-English Summary (8th-Grade Level)
This is a study to investigate the efficacy and safety of ADP-A2M4 in HLA-A\*02 eligible and MAGE-A4 positive subjects with metastatic or inoperable (advanced) Synovial Sarcoma (Cohort 1, 2 and 3 ) or MRCLS (Cohort 1) .
Who can join: Review the eligibility criteria below.
Location: City of Hope β Duarte, California
Age range: 10 Years to 75 Years
π§ͺ Interventions in This Study
- afamitresgene autoleucel (previously ADP-A2M4) (GENETIC)
π "Do I Qualify?" β 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria β
π All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- City of Hope β Duarte, California
- Stanford Cancer Center β Palo Alto, California
- University of Colorado β Aurora, Colorado
- Mayo Clinic Jacksonville β Jacksonville, Florida
- Moffitt Cancer Center β Tampa, Florida
- Northwestern University Robert H. Lurie Comprehensive Cancer Center β Chicago, Illinois
- National Cancer Institute β Bethesda, Maryland
- Massachusetts General Hospital β Boston, Massachusetts
- Dana Farber Cancer Institute β Boston, Massachusetts
- University of Michigan β Ann Arbor, Michigan
- Washington University School of Medicine β St Louis, Missouri
- Memorial Sloan-Kettering Cancer Center β New York, New York
- Ohio State University β Columbus, Ohio
- Vanderbilt β Nashville, Tennessee
- MD Anderson Cancer Center β Houston, Texas
- Fred Hutch β Seattle, Washington
- Medical College of WI Froedtert Hospital β Milwaukee, Wisconsin
- Princess Margaret Cancer Centre β Toronto, Ontario
- Centre Leon Berard β Lyon,
- Hospital Haut Leveque, CHU Bordeaux β Pessac,
- Gustave Roussy Cancer Center β Villejuif,
- Hospital Universitari Vall D'Hebron β Barcelona, Catalonia
- Start Madrid-FJD, FundaciΓ³n JimΡnez DΓaz β Madrid,
- Hospital Universitario Virgen del Rocio β Seville,
- UCLH Cancer Clinical Trials Unit β London,
π Contact the Study Coordinator
Phone: (800) 826-4673
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
π° Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Synovial Sarcoma
- Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 β Houston, Texas
- SPEARHEAD-3 Pediatric Study β Palo Alto, California
- Synovial Sarcoma Registry / Biospecimen Repository β Philadelphia, Pennsylvania
Explore by condition: All Synovial Sarcoma clinical trials
π‘ How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.