SPEARHEAD-3 Pediatric Study (NCT05642455)
A Phase 1/2 Open Label, Basket Study to Assess the Safety, Tolerability and Anti-Tumor Activity of Afamitresgene Autoleucel in Pediatric Subjects With MAGE-A4 Positive Tumors
🩺 Plain-English Summary (8th-Grade Level)
This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers.
Who can join: Review the eligibility criteria below.
Location: Stanford University — Palo Alto, California
Age range: 2 Years to 21 Years
🧪 Interventions in This Study
- Afamitresgene autoleucel (GENETIC)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Stanford University — Palo Alto, California
- National Institutes of Health — Bethesda, Maryland
- Dana Farber Cancer Institute — Boston, Massachusetts
- Washington University — St Louis, Missouri
- Memorial Sloan Kettering Kids — New York, New York
- Duke University School of Medicine — Durham, North Carolina
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio
- Children's Hospital of Philedephia — Philadelphia, Pennsylvania
- Seattle Children's Hospital — Seattle, Washington
- University of Wisconsin Cancer Center — Madison, Wisconsin
📞 Contact the Study Coordinator
Phone: (650) 788-6811
Email: ali4@stanford.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.