Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease (NCT04114981)
Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared With Fractionated SRS for Resected Metastatic Brain Disease
🩺 Plain-English Summary (8th-Grade Level)
This phase III trial studies how well single fraction stereotactic radiosurgery works compared with fractionated stereotactic radiosurgery in treating patients with cancer that has spread to the brain from other parts of the body and has been removed by surgery. Single fraction stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Fractionated stereotactic radiosurgery delivers multiple, smaller doses of radiation therapy over time. This study may help doctors find out if fractionated stereotactic radiosurgery is better or worse than the usual approach with single fraction stereotactic radiosurgery.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
- Single Fraction Stereotactic Radiosurgery (RADIATION)
- Fractionated Stereotactic Radiosurgery (RADIATION)
- Quality-of-Life Assessment (PROCEDURE)
- Questionnaire Administration (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (232 Sites)
Showing the first 25 of 232 sites.
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- Anchorage Radiation Therapy Center — Anchorage, Alaska
- Banner MD Anderson Cancer Center — Gilbert, Arizona
- Banner Thunderbird Medical Center — Glendale, Arizona
- Banner-University Medical Center Phoenix — Phoenix, Arizona
- Mayo Clinic Hospital in Arizona — Phoenix, Arizona
- Mayo Clinic in Arizona — Scottsdale, Arizona
- University of Arizona Cancer Center-North Campus — Tucson, Arizona
- Mercy Hospital Fort Smith — Fort Smith, Arkansas
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas
- UC San Diego Moores Cancer Center — La Jolla, California
- Los Angeles County-USC Medical Center — Los Angeles, California
- USC / Norris Comprehensive Cancer Center — Los Angeles, California
- Epic Care Cyberknife Center — Walnut Creek, California
- University of Colorado Hospital — Aurora, Colorado
- UCHealth Memorial Hospital Central — Colorado Springs, Colorado
- Yale University — New Haven, Connecticut
- Helen F Graham Cancer Center — Newark, Delaware
- Beebe Health Campus — Rehoboth Beach, Delaware
- Boca Raton Regional Hospital — Boca Raton, Florida
- Morton Plant Hospital — Clearwater, Florida
- UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida
- Mayo Clinic in Florida — Jacksonville, Florida
- University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Metastatic Malignant Neoplasm in the Brain
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- Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases — Phoenix, Arizona
- Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases — Columbus, Ohio
- Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases — Houston, Texas
- Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases — Columbus, Ohio
- nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex — Houston, Texas
Explore by condition: All Metastatic Malignant Neoplasm in the Brain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.