Statins for Venous Event Reduction in Patients With Venous Thromboembolism (NCT04319627)
🩺 Plain-English Summary (8th-Grade Level)
The standard or usual treatment for patients diagnosed with deep vein thrombosis or pulmonary embolism is treatment with blood thinners (called anticoagulants). While treatment of blood clots with blood thinners is effective, some research has shown that adding a statin (medication used to lower cholesterol) may give extra protection. It is thought that statins can improve how cells along the walls of the vein control inflammation, which can prevent new blood clots from forming. The medication in this study, rosuvastatin, is approved in Canada for use as a cholesterol-lowering medication. The use of rosuvastatin in this study is considered investigational. This means that Health Canada has not approved the use of rosuvastatin as a treatment for blood clots. However, it has been approved for use in this research study. The purpose of this study is to examine if adding a statin (rosuvastatin) to the usual blood thinner treatment will decrease the risk of another blood clot forming. The investigators also hope to discover if taking a statin reduces damage to your veins. To do this, some of the participants in this study will get rosuvastatin and others will receive a placebo (a substance that looks like the study rosuvastatin but does not have any active or medicinal ingredients). The placebo in this study is not intended to have any effect on your blood clot. A placebo is used to make the results of the study more reliable.
Who can join: Review the eligibility criteria below.
Location: Foothills Medical Centre — Calgary, Alberta
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (31 Sites)
Showing the first 25 of 31 sites.
- Foothills Medical Centre — Calgary, Alberta
- Queen Elizabeth II Hospital — Halifax, Nova Scotia
- Hamilton General Hospital — Hamilton, Ontario
- St. Joseph's Healthcare — Hamilton, Ontario
- Juravinski Hospital — Hamilton, Ontario
- The Ottawa Hospital — Ottawa, Ontario
- Hôpital Montfort — Ottawa, Ontario
- Niagara Health - St. Catharines Site — St. Catharines, Ontario
- Sunnybrook Hospital — Toronto, Ontario
- University Health Network — Toronto, Ontario
- Jewish General Hospital — Montreal, Quebec
- McGill Univeristy Health Centre — Montreal, Quebec
- CIUSSS de-l'Ouest-de-l'Ile-de-Montreal -St. Mary's Hospital Center — Montreal, Quebec
- CHU de Quebec-Université Laval — Québec, Quebec
- CHU d'Angers - Service d'accueil et traitement des Urgences — Angers,
- Brest University Hospital Centre — Brest,
- CHU de Clermont-Ferrand, Hôpital Gabriel Montpied — Clermont-Ferrand,
- APHP Hôpital Louis Mourier — Colombes,
- CHU de Dijon - Service d'imagerie diagnostique et thérapeutique — Dijon,
- GH La Rochelle - Ré-Aunis - Service de Médecine vasculaire — La Rochelle,
- Centre Hospitalier Universitaire De Saint Etienne — Saint-Etienne,
- CHI Toulon - La Seyne sur Mer - Hôpital Sainte Musse — Toulon,
- Mater Misericordiae University Hospital — Dublin,
- University of Insubria — Varese,
- Ostfold Hopsital — Sarpsborg,
📞 Contact the Study Coordinator
Phone: (613) 737-8899
Email: jbrinkhurst@ohri.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Venous Thromboembolism
- Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery — Charleston, South Carolina
- Using a Blood Test and Software Tool to Guide Treatment for Venous Thromboembolism — Basking Ridge, New Jersey
- Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty — Miami, Florida
- Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters — Halifax, Nova Scotia
- DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis — Scottsdale, Arizona
- Secondary Prevention of VTE in Patients With Cancer and Catheter-Related Upper Extremity Deep Vein Thrombosis — Ottawa, Ontario
Explore by condition: All Venous Thromboembolism clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.