Pulmonary Embolism International THrOmbolysis Study-3 (NCT04430569)
A Reduced Dose of Thrombolytic Treatment for Patients With Intermediate High-risk Acute Pulmonary Embolism: a Randomized Controled Trial
🩺 Plain-English Summary (8th-Grade Level)
In this study, we will assess the efficacy and safety of a reduced dose of thrombolytic therapy given in addition to low-molecular-weight heparin in patients with intermediate-high-risk acute pulmonary embolism. Half of participants will receive thrombolytic treatment, while the other half will receive a placebo.
Who can join: Review the eligibility criteria below.
Location: Ordensklinikum Linz GmbH Elisabethinen — Linz
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (85 Sites)
Showing the first 25 of 85 sites.
- Ordensklinikum Linz GmbH Elisabethinen — Linz,
- UCL Brussels — Brussels,
- KU Leuven — Leuven,
- CHU Liège — Liège,
- Foothills Medical Centre — Calgary, Alberta
- Juravinski Hospital - Hamilton Health Sciences Corporation — Hamilton, Ontario
- Hamilton General Hospital - Hamilton Health Sciences Corporation — Hamilton, Ontario
- Kingston Health Sciences Centre — Kingston, Ontario
- London Health Sciences Centre — London, Ontario
- The Ottawa Hopsital, General and Civic campuses — Ottawa, Ontario
- Jewish General Hospital — Montreal, Quebec
- CHU d'Angers — Angers,
- CHU de Besançon - Hôpital Jean-Minjoz — Besançon,
- CHU de Brest - Hôpital de la Cavale Blanche — Brest,
- CHU de Tours - Hôpital Trousseau — Chambray-lès-Tours,
- CHU de Clermont-Ferrand - Hôpital Gabriel Montpied — Clermont-Ferrand,
- AP-HP - hôpital Henri-Mondor — Créteil,
- CHU de Grenoble - Hôpital Michallon — La Tronche,
- AP-HP - hôpital Bicêtre — Le Kremlin-Bicêtre,
- HCL - Hôpital Edouard Herriot — Lyon,
- HCL - Centre Hospitalier Lyon-Sud, Pierre-Bénite — Lyon,
- AP-HM - Hôpital de la Timone — Marseille,
- CHU de Nice - Hôpital Pasteur — Nice,
- AP-HP - hôpital européen Georges-Pompidou — Paris,
- AP-HP - Hôpital Bichat-Claude-Bernard — Paris,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Pulmonary Embolism
- Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism — Birmingham, Alabama
- Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial — Phoenix, Arizona
- Comparing Electrical Impedance Tomography to Computed Tomographic Angiography — Loveland, Colorado
- Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE — Bay Shore, New York
- Michigan Emergency Department Improvement Collaborative (MEDIC) Alert; Pulmonary Embolism (PE) — Ann Arbor, Michigan
Explore by condition: All Pulmonary Embolism clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.