🏛️ Verified NIH Record • Updated 2026-06-29
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial (NCT05408546)
Evaluation of the Safety and Thrombolytic Effects of Ascending Doses of TS23 in Subjects With Intermediate-Risk (Sub-Massive) Acute Pulmonary Embolism
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Translational Sciences, Inc.
🩺 Plain-English Summary (8th-Grade Level)
Phase II trial of TS23
Who can join: Review the eligibility criteria below.
Location: Banner University Medical Center — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (13 Sites)
- Banner University Medical Center — Phoenix, Arizona
- Banner University Medical Center - Tucson — Tucson, Arizona
- Cedars Sinai Medical Center — Los Angeles, California
- Cottage Hospital — Santa Barbara, California
- Wellstar MCG Health Medical Center — Augusta, Georgia
- Lifebridge Health — Baltimore, Maryland
- Tuft University Hospital — Boston, Massachusetts
- Henry Ford Hospital — Detroit, Michigan
- Wake Forest University/Atrium Health's Carolinas Medical Center — Winston-Salem, North Carolina
- Fairview Hospital — Cleveland, Ohio
- Cleveland Clinic — Cleveland, Ohio
- Temple University Hospital — Philadelphia, Pennsylvania
- Texas Tech University Health Sciences Center at El Paso — El Paso, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE — Bay Shore, New York
- Michigan Emergency Department Improvement Collaborative (MEDIC) Alert; Pulmonary Embolism (PE) — Ann Arbor, Michigan
- Pulmonary Embolism International THrOmbolysis Study-3 — Linz,
Explore by condition: All Pulmonary Embolism clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.