🏛️ Verified NIH Record • Updated 2024-08-07
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) (NCT04433858)
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Sheppard Pratt Health System
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to evaluate the efficacy of psilocybin (25 mg) administered under supportive conditions to adult participants with severe TRD, in improving depressive symptoms.
Who can join: Review the eligibility criteria below.
Location: VA Palo Alto Healthcare System/Stanford Medicine — Palo Alto, California
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- VA Palo Alto Healthcare System/Stanford Medicine — Palo Alto, California
- Sheppard Pratt Health System — Baltimore, Maryland
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Treatment Resistant Depression
- Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S — Atlanta, Georgia
- Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression — Atlanta, Georgia
- Rapid Acting Transcranial Magnetic Stimulation — Stanford, California
- Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD) — Rochester, Minnesota
- Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression — Stanford, California
Explore by condition: All Treatment Resistant Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.