Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression (NCT05774665)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not responded well to standard antidepressant treatment. The main questions it seeks to answer are: 1. Do omega-3 fatty acids added to ineffective antidepressant treatment increase production of compounds that reduce inflammation? 2. Is the increase in these anti-inflammatory compounds associated with a stronger antidepressant effect? Participants taking antidepressants that have not worked completely will be assigned at random for a 12-week period to one of the following: 1. an omega-3 preparation 2. an inactive placebo During the course of the study, blood tests will be obtained for compounds associated with inflammation, and questionnaires to measure clinical improvement in depressive symptoms will be administered.
Who can join: Review the eligibility criteria below.
Location: Emory University School of Medicine — Atlanta, Georgia
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Emory University School of Medicine — Atlanta, Georgia
- Depression Clinical and Research Program at Massachusetts General Hospital — Boston, Massachusetts
- University of Utah — Salt Lake City, Utah
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Treatment Resistant Depression
- Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S — Atlanta, Georgia
- An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) — Palo Alto, California
- Rapid Acting Transcranial Magnetic Stimulation — Stanford, California
- Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD) — Rochester, Minnesota
- Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression — Stanford, California
Explore by condition: All Treatment Resistant Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.