πŸ›οΈ Verified NIH Record β€’ Updated 2026-06-15

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease (NCT04639050)

A Phase Ib/IIa, Randomized, Double Blind, Placebo-Controlled, Multiple Ascending Dose, Parallel-Group Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Patients With Prodromal or Mild to Moderate Alzheimer's Disease

πŸ”΅ Active, Not Recruiting Phase1 / Phase2 πŸ’Š Investigational Drug / Biologic Sponsor: Hoffmann-La Roche

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the safety, tolerability, immunogenicity, pharmacokinetics, and pharmacodynamics of multiple-ascending intravenous (IV) doses of RO7126209 in participants with prodromal or mild to moderate Alzheimer's disease (AD), who are amyloid positive based on amyloid positron emission tomography (PET) scan.

Who can join: Review the eligibility criteria below.

Location: JEM Research LLC β€” Atlantis, Florida

Age range: 50 Years to 85 Years

πŸ§ͺ Interventions in This Study

πŸ“‹ "Do I Qualify?" β€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria β†—

πŸ“ All Participating Trial Locations (41 Sites)

Showing the first 25 of 41 sites.

  • JEM Research LLC β€” Atlantis, Florida
  • K2 Medical Research-Winter Garden β€” Clermont, Florida
  • K2 Medical Research - The Villages β€” Lady Lake, Florida
  • K2 Medical Research, LLC β€” Maitland, Florida
  • Optimus U Corp β€” Miami, Florida
  • Charter Research - Winter Park/Orlando β€” Orlando, Florida
  • Advent Health Orlando β€” Orlando, Florida
  • Alzheimer's Research and Treatment Center β€” Stuart, Florida
  • Charter Research - Lady Lake/The Villages β€” The Villages, Florida
  • Alzheimer?s Research and Treatment Center β€” Wellington, Florida
  • Conquest Research, LLC β€” Winter Park, Florida
  • Alzheimer's Research and Treatment Center - Columbus β€” Columbus, Georgia
  • Center for Advanced Research & Education β€” Gainesville, Georgia
  • Quest Research Institute β€” Farmington Hills, Michigan
  • Summit Research Network Inc. β€” Portland, Oregon
  • Abington Neurological Associates β€” Abington, Pennsylvania
  • Kerwin Research Center, LLC β€” Dallas, Texas
  • Heidelberg Repatriation Hospital β€” Heidelberg West, Victoria
  • Alfred Hospital β€” Melbourne, Victoria
  • Richmond Clinical Trials β€” Richmond, British Columbia
  • Toronto Memory Program β€” Toronto, Ontario
  • Centro de InvestigaciΓ³n ClΓ­nica UC-CICUC β€” Santiago,
  • Hospital Clinico Univ de Chile β€” Santiago,
  • Yokohama City Minato Red Cross Hospital β€” Kanagawa,
  • Koseikai Takeda Hospital β€” Kyoto,

πŸ’° Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

πŸ’‘ How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
πŸ›οΈ View Official NIH Record β†—