Neural Bases of Vocal Sensorimotor Impairment in Aphasia (NCT04742894)
🩺 Plain-English Summary (8th-Grade Level)
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.
Who can join: Review the eligibility criteria below.
Location: University of California Irvine — Irvine, California
Age range: 21 Years to 75 Years
🧪 Interventions in This Study
- Visual Feedback Training (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- University of California Irvine — Irvine, California
- University of South Carolina — Columbia, South Carolina
- The University of Texas at Dallas — Richardson, Texas
📞 Contact the Study Coordinator
Phone: (972) 883-3062
Email: roozbeh.behroozmand@utdallas.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aphasia
- Semantic Feature Analysis Treatment for Aphasia — Pittsburgh, Pennsylvania
- Genetic and Cognitive Predictors of Aphasia Treatment Response — Columbus, Ohio
- Treatment Outcomes With tDCS in Post-Stroke Aphasia — Little Rock, Arkansas
- Brain-based Understanding of Individual Language Differences After Stroke — Washington D.C., District of Columbia
- HD-tDCS for Phonological Impairment in Aphasia — Milwaukee, Wisconsin
- Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia — Elkins Park, Pennsylvania
Explore by condition: All Aphasia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.