Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain (NCT04809376)
A 2-stage, Adaptive, Randomised, Double-blind, Placebo-controlled, Multicentre Study to Evaluate Dose and Treatment Effect of Pentosan Polysulfate Sodium Compared With Placebo in Participants With Knee Osteoarthritis Pain
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis pain. Study details include: * The study duration will be up to 31 weeks per participant * The treatment duration will be 6 weeks. * The visit frequency will be twice weekly during treatment. * The visit frequency will be every 4 weeks during the follow-up period.
Who can join: Review the eligibility criteria below.
Location: Alliance for Multispecialty Research - Tempe — Tempe, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (33 Sites)
Showing the first 25 of 33 sites.
- Alliance for Multispecialty Research - Tempe — Tempe, Arizona
- Fiel Family and Sports Medicine — Tempe, Arizona
- Tucson Orthopaedic Institute — Tucson, Arizona
- Core Healthcare Group — Cerritos, California
- Biosolutions Clinical Research Center — La Mesa, California
- Providence Clinical Research — North Hollywood, California
- Prospective Research Innovations Inc. — Rancho Cucamonga, California
- Encompass Clinical Research — Spring Valley, California
- Clinical Research of West Florida- Clearwater — Clearwater, Florida
- University Clinical Research-Deland — DeLand, Florida
- LMG Research — Miami, Florida
- Well Pharma Medical Research, Corp. — Miami, Florida
- Progressive Medical Research — Port Orange, Florida
- Clinical Research of West Florida — Tampa, Florida
- Conquest Research — Winter Park, Florida
- Northwestern University Feinberg School of Medicine — Chicago, Illinois
- Alliance for Multispecialty Research - Newton — Newton, Kansas
- Alliance for Multispecialty Research - Wichita West — Wichita, Kansas
- Alliance for Multispecialty Research - Wichita East — Wichita, Kansas
- Tandem Clinical Research — Marrero, Louisiana
- Alliance for Multispecialty Research - Las Vegas — Las Vegas, Nevada
- Kaplan Medical Research — Las Vegas, Nevada
- Coastal Carolina Research Center — North Charleston, South Carolina
- Alliance for Multispecialty Research - Knoxville — Knoxville, Tennessee
- FutureSearch Trials - Austin — Austin, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.