Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008). (NCT04895722)

🧪 Interventions in This Study

• Pembrolizumab (BIOLOGICAL)
• Pembrolizumab/Quavonlimab (BIOLOGICAL)
• Pembrolizumab/Favezelimab (BIOLOGICAL)
• Pembrolizumab/Vibostolimab (BIOLOGICAL)
• MK-4830 (BIOLOGICAL)

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (109 Sites)

Showing the first 25 of 109 sites.

• Mid Florida Cancer Center ( Site 1519) — Orange City, Florida
• University Cancer & Blood Center, LLC ( Site 1521) — Athens, Georgia
• University of Chicago Medical Center-Medicine - Section of Hematology/Oncology - Gastrointestinal P — Chicago, Illinois
• Icahn School of Medicine at Mount Sinai ( Site 1528) — New York, New York
• Hematology Oncology Associates of Rockland ( Site 1525) — Nyack, New York
• UPMC Hillman Cancer Center ( Site 1516) — Pittsburgh, Pennsylvania
• The West Clinic, PLLC dba West Cancer Center ( Site 1576) — Germantown, Tennessee
• Vanderbilt University Medical Center-Vanderbilt-Ingram Cancer Center ( Site 1509) — Nashville, Tennessee
• UT Southwestern Medical Center ( Site 1551) — Dallas, Texas
• Baylor Scott & White Medical Center - Temple-Division of Hematology/Oncology ( Site 1549) — Temple, Texas
• Northwest Medical Specialties, PLLC ( Site 1546) — Tacoma, Washington
• UZ Brussel ( Site 0105) — Brussels, Bruxelles-Capitale, Region de
• Cliniques universitaires Saint-Luc-Medical Oncology ( Site 0104) — Brussels, Bruxelles-Capitale, Region de
• Université Catholique de Louvain-Namur - Centre Hospitalier -Oncology ( Site 0102) — Yvoir, Namur
• UZ Leuven ( Site 0101) — Leuven, Vlaams-Brabant
• AZ Delta vzw ( Site 0106) — Roeselare, West-Vlaanderen
• The Moncton Hospital-Oncology ( Site 0307) — Moncton, New Brunswick
• Sunnybrook Research Institute - Odette Cancer Centre ( Site 0316) — Toronto, Ontario
• McGill University Health Centre-CIM - Oncology ( Site 0306) — Montreal, Quebec
• Instituto de Cancerología ( Site 1610) — Medellín, Antioquia
• Fundación Colombiana de Cancerología Clínica Vida ( Site 1606) — Medellín, Antioquia
• Clinica de la Costa S.A.S. ( Site 1608) — Barranquilla, Atlántico
• Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 1611) — Bogotá, Bogota D.C.
• Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 1601) — Valledupar, Cesar Department
• Oncomédica S.A.S ( Site 1602) — Montería, Departamento de Córdoba

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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• Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver — Basking Ridge, New Jersey
• The PRIME-CRC Trial to Promote CRC Screening in Rural Communities — Bastrop, Louisiana
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Explore by condition: All Colorectal Cancer clinical trials

💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Review the official NIH record below to find the coordinating site.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.