Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma (NCT04910022)
A Phase I/II Combination Study of NMS-03305293 and Temozolomide in Adult Patients With Recurrent Glioblastoma
๐ฉบ Plain-English Summary (8th-Grade Level)
Multicenter, open-label, single-arm Phase 1/2 study on the safety and efficacy of the combination of NMS-03305293 and temozolomide (TMZ) in adult patients with diffuse gliomas (Phase 1) and isocitrate dehydrogenase (IDH) wild type glioblastoma (Phase 2) at first relapse.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic Hospital - Phoenix โ Phoenix, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (18 Sites)
- Mayo Clinic Hospital - Phoenix โ Phoenix, Arizona
- University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center โ Orange, California
- Mayo Clinic Florida โ Jacksonville, Florida
- Dana-Farber Cancer Institute โ Boston, Massachusetts
- Mayo Clinic Cancer Center โ Rochester, Minnesota
- Memorial Sloan-Kettering Cancer Center โ New York, New York
- UT Southwestern Medical Center โ Dallas, Texas
- The University of Texas MD Anderson Cancer Center โ Houston, Texas
- University of Utah, University Hospital โ Salt Lake City, Utah
- University of Virginia Health System โ Charlottesville, Virginia
- Swedish Medical Center - First Hill Campus โ Seattle, Washington
- IRCCS Istituto delle Scienze Neurologiche di Bologna โ Bologna,
- IRCCS Istituto Neurologico Carlo Besta โ Milan,
- Istituto Oncologico Veneto - IRCCS โ Padova,
- Istituto Clinico Humanitas โ Rozzano,
- Erasmus Medical Center โ Rotterdam,
- PanOncology Trials (Pan American Center for Oncology Trials, LLC) โ Rio Piedras,
- University Hospital Zurich โ Zurich,
๐ Contact the Study Coordinator
Phone: (800) 664-4580
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Glioblastoma
- Analyzing Pulsed Reduced Dose Radiotherapy in Upfront Glioblastoma โ Milwaukee, Wisconsin
- A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent. โ New York, New York
- A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors โ San Francisco, California
- Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma โ Phoenix, Arizona
- A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma โ Birmingham, Alabama
- Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma โ Fairbanks, Alaska
Explore by condition: All Glioblastoma clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.