๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2025-08-18

Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma (NCT04910022)

A Phase I/II Combination Study of NMS-03305293 and Temozolomide in Adult Patients With Recurrent Glioblastoma

๐Ÿ”ต Active, Not Recruiting Phase1 / Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Nerviano Medical Sciences

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Multicenter, open-label, single-arm Phase 1/2 study on the safety and efficacy of the combination of NMS-03305293 and temozolomide (TMZ) in adult patients with diffuse gliomas (Phase 1) and isocitrate dehydrogenase (IDH) wild type glioblastoma (Phase 2) at first relapse.

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic Hospital - Phoenix โ€” Phoenix, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (18 Sites)

  • Mayo Clinic Hospital - Phoenix โ€” Phoenix, Arizona
  • University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center โ€” Orange, California
  • Mayo Clinic Florida โ€” Jacksonville, Florida
  • Dana-Farber Cancer Institute โ€” Boston, Massachusetts
  • Mayo Clinic Cancer Center โ€” Rochester, Minnesota
  • Memorial Sloan-Kettering Cancer Center โ€” New York, New York
  • UT Southwestern Medical Center โ€” Dallas, Texas
  • The University of Texas MD Anderson Cancer Center โ€” Houston, Texas
  • University of Utah, University Hospital โ€” Salt Lake City, Utah
  • University of Virginia Health System โ€” Charlottesville, Virginia
  • Swedish Medical Center - First Hill Campus โ€” Seattle, Washington
  • IRCCS Istituto delle Scienze Neurologiche di Bologna โ€” Bologna,
  • IRCCS Istituto Neurologico Carlo Besta โ€” Milan,
  • Istituto Oncologico Veneto - IRCCS โ€” Padova,
  • Istituto Clinico Humanitas โ€” Rozzano,
  • Erasmus Medical Center โ€” Rotterdam,
  • PanOncology Trials (Pan American Center for Oncology Trials, LLC) โ€” Rio Piedras,
  • University Hospital Zurich โ€” Zurich,

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 664-4580

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Glioblastoma clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—