🏛️ Verified NIH Record • Updated 2025-08-05
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06) (NCT05002127)
A Phase 2/3 Study of Evorpacept (ALX148) in Patients With Advanced HER2-Overexpressing Gastric/Gastroesophageal Junction Adenocarcinoma (ASPEN-06)
🔵 Active, Not Recruiting Phase2 / Phase3 💊 Investigational Drug / Biologic Sponsor: ALX Oncology Inc.
🩺 Plain-English Summary (8th-Grade Level)
A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.
Who can join: Review the eligibility criteria below.
Location: The Oncology Institute of Hope & Innovation — Anaheim, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (83 Sites)
Showing the first 25 of 83 sites.
- The Oncology Institute of Hope & Innovation — Anaheim, California
- University of California Los Angeles — Los Angeles, California
- Vanderbilt University Medical Center — Nashville, Tennessee
- NEXT Virginia — Fairfax, Virginia
- Fred Hutchinson Cancer Center — Seattle, Washington
- Icon Cancer Centre Southport — Southport, Queensland
- Monash Medical Centre — Clayton, Victoria
- Universitair Ziekenhuis Antwerpen — Antwerp,
- Universitair Ziekenhuis Leuven - Campus Gasthuisberg — Leuven,
- Centre Hospitalier Universitaire de Liège — Liège,
- Fakultní Nemocnice Hradec Králové — Hradec Králové,
- Fakultní Nemocnice Olomouc — Olomouc,
- Vseobecna Fakultni Nemocnice v Praze — Prague,
- Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz — Besançon,
- Centre Hospitalier Universitaire de Bordeaux — Bordeaux,
- Hôpital Morvan — Brest,
- Centre Léon Bérard — Lyon,
- Hôpital Privé Jean Mermoz — Lyon,
- Institut Paoli-Calmettes — Marseille,
- Hôpital Saint-Antoine — Paris,
- Hôpital Trousseau — Paris,
- Hôpital Rangueil — Toulouse,
- Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi — Catania,
- Azienda Ospedaliero - Universitaria Careggi — Florence,
- Fondazione IRCCS - Istituto Nazionale dei Tumori — Milan,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Gastric Cancer
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- Study to Assess the Safety, Tolerability, and Efficacy of IDX-1197 in Combination With XELOX or Irinotecan in Patients With Advanced Gastric Cancer — Los Angeles, California
- Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03) — Baltimore, Maryland
- Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer — Baltimore, Maryland
- Study for AZD4360 in Participants With Advanced Solid Tumours — Santa Monica, California
- Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma — Tampa, Florida
Explore by condition: All Gastric Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.