🏛️ Verified NIH Record • Updated 2025-08-05

A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06) (NCT05002127)

A Phase 2/3 Study of Evorpacept (ALX148) in Patients With Advanced HER2-Overexpressing Gastric/Gastroesophageal Junction Adenocarcinoma (ASPEN-06)

🔵 Active, Not Recruiting Phase2 / Phase3 💊 Investigational Drug / Biologic Sponsor: ALX Oncology Inc.

🩺 Plain-English Summary (8th-Grade Level)

A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.

Who can join: Review the eligibility criteria below.

Location: The Oncology Institute of Hope & Innovation — Anaheim, California

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (83 Sites)

Showing the first 25 of 83 sites.

  • The Oncology Institute of Hope & Innovation — Anaheim, California
  • University of California Los Angeles — Los Angeles, California
  • Vanderbilt University Medical Center — Nashville, Tennessee
  • NEXT Virginia — Fairfax, Virginia
  • Fred Hutchinson Cancer Center — Seattle, Washington
  • Icon Cancer Centre Southport — Southport, Queensland
  • Monash Medical Centre — Clayton, Victoria
  • Universitair Ziekenhuis Antwerpen — Antwerp,
  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg — Leuven,
  • Centre Hospitalier Universitaire de Liège — Liège,
  • Fakultní Nemocnice Hradec Králové — Hradec Králové,
  • Fakultní Nemocnice Olomouc — Olomouc,
  • Vseobecna Fakultni Nemocnice v Praze — Prague,
  • Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz — Besançon,
  • Centre Hospitalier Universitaire de Bordeaux — Bordeaux,
  • Hôpital Morvan — Brest,
  • Centre Léon Bérard — Lyon,
  • Hôpital Privé Jean Mermoz — Lyon,
  • Institut Paoli-Calmettes — Marseille,
  • Hôpital Saint-Antoine — Paris,
  • Hôpital Trousseau — Paris,
  • Hôpital Rangueil — Toulouse,
  • Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi — Catania,
  • Azienda Ospedaliero - Universitaria Careggi — Florence,
  • Fondazione IRCCS - Istituto Nazionale dei Tumori — Milan,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Gastric Cancer clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗