Blood Purification for the Treatment of Pathogen Associated Shock (NCT05011656)
Blood Purification for the Treatment of Critically Ill Patients With Pathogen Associated Shock: A Multicenter, Randomized Controlled Feasibility Trial
🩺 Plain-English Summary (8th-Grade Level)
This study is a multi-center, randomized controlled feasibility trial to evaluate the initial safety and efficacy of a novel extracorporeal blood purification (EBP) therapy in critically ill patients with pathogen associated shock across 15 U.S. sites. Adults (18 years old and older) admitted to the ICU with all of the following: • Pathogen associated shock defined as: * The need for vasopressors to maintain mean arterial pressure (MAP) ≥ 65 mmHg despite adequate fluid resuscitation * Presence of a pathogen detected in the bloodstream within 72 hours of screening using commercially available in-vitro diagnostic testing
Who can join: Review the eligibility criteria below.
Location: George Washington University — Washington D.C., District of Columbia
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- George Washington University — Washington D.C., District of Columbia
- Southeast Georgia Health System, Inc. — Brunswick, Georgia
- University of Michigan — Ann Arbor, Michigan
- Mayo Clinic — Rochester, Minnesota
- Good Samaritan Hospital — Corvallis, Oregon
- Trinity Health Mid Atlantic-SMMC — Langhorne, Pennsylvania
- University of Texas Southwestern Medical Center — Dallas, Texas
- Methodist Hospital — San Antonio, Texas
- University of Texas Health Science Center at San Antonio (UT Health San Antonio) — San Antonio, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock — London, Ontario
- Evaluating Dynamic Arterial Elastance in Septic Shock Patients. — Bogotá,
- Randomized Control Study in REsuscitation of SEpsis Trial — Bogotá, Bogota D.C.
Explore by condition: All Septic Shock clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.